The transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of their continuous presence during development and in the differentiated state they shape the oligodendroglial regulatory network at all times. In this review, we exploit their eminent role and omnipresence to elaborate the central principles that organize the gene regulatory network in oligodendrocytes in such a way that it preserves its identity, but at the same time allows defined and stimulus-dependent changes that result in an ordered lineage progression, differentiation, and myelination. For this purpose, we outline the multiple functional and physical interactions and intricate cross-regulatory relationships with other transcription factors, such as Hes5, Id, and SoxD proteins, in oligodendrocyte precursors and Tcf7l2, Sip1, Nkx2.2, Zfp24, and Myrf during differentiation and myelination, and interpret them in the context of the regulatory network.

中文翻译：

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利用谱系决定子 Olig2 和 Sox10 探索少突胶质细胞发育的转录调控

转录因子 Olig2 和 Sox10 共同定义了少突胶质细胞的身份。由于它们在发育过程中持续存在并处于分化状态，它们始终塑造着少突胶质细胞的调节网络。在这篇综述中，我们利用它们的突出作用和无所不在来阐述组织少突胶质细胞中基因调控网络的中心原则，使其保持其身份，但同时允许定义和刺激依赖性变化，从而导致有序的谱系进展、分化和髓鞘形成。为此，我们概述了在少突胶质细胞前体和 Tcf7l2、Sip1、Nkx2.2、Zfp24、