Biodegradable Small-Scale Swimmers for Biomedical Applications,Advanced Materials

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Biodegradable Small-Scale Swimmers for Biomedical Applications
Advanced Materials ( IF 27.4 ) Pub Date : 2021-09-03 , DOI: 10.1002/adma.202102049
Joaquin Llacer-Wintle ₁ , Antón Rivas-Dapena ₁ , Xiang-Zhong Chen ₁ , Eva Pellicer ₂ , Bradley J Nelson ₁ , Josep Puigmartí-Luis _{3,

4} , Salvador Pané ₁

Affiliation

Most forms of biomatter are ephemeral, which means they transform or deteriorate after a certain time. From this perspective, implantable healthcare devices designed for temporary treatments should exhibit the ability to degrade and either blend in with healthy tissues, or be cleared from the body with minimal disruption after accomplishing their designated tasks. This topic is currently being investigated in the field of biomedical micro- and nanoswimmers. These tiny devices have the ability to move through fluids by converting physical or chemical energy into motion. Several architectures of these devices have been designed to mimic the motion strategies of nature's motile microorganisms and cells. Due to their motion abilities, these devices have been proposed as minimally invasive tools for precision healthcare applications. Hence, a natural progression in this field is to produce motile structures that can adopt, or even surpass, similar transient features as biological systems. The fate of small-scale swimmers after accomplishing their therapeutic mission is critical for the successful translation of small-scale swimmers’ technologies into clinical applications. In this review, recent research efforts are summarized on the topic of biodegradable micro- and nanoswimmers for biomedical applications, with a focus on targeted therapeutic delivery.

中文翻译：

用于生物医学应用的可生物降解小型游泳者

大多数形式的生物物质都是短暂的，这意味着它们在一定时间后会发生变化或变质。从这个角度来看，为临时治疗而设计的植入式医疗设备应该表现出降解并与健康组织融合的能力，或者在完成指定任务后以最小的干扰从体内清除。该主题目前正在生物医学微型和纳米游泳者领域进行研究。这些微型设备能够通过将物理或化学能转化为运动来在流体中移动。这些设备的几种架构已被设计为模拟自然界的活动微生物和细胞的运动策略。由于它们的运动能力，这些设备已被提议作为精密医疗保健应用的微创工具。因此，该领域的一个自然进展是产生可以采用甚至超越与生物系统类似的瞬态特征的运动结构。小型游泳运动员在完成治疗任务后的命运对于将小型游泳运动员的技术成功转化为临床应用至关重要。在这篇综述中，最近的研究工作总结了生物医学应用中可生物降解的微型和纳米游泳器的主题，重点是靶向治疗。

更新日期：2021-10-20

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