当前位置：
X-MOL 学术
›
ACS Biomater. Sci. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Surface Modification of Nanofibers by Physical Adsorption of Fiber-Homologous Amphiphilic Copolymers and Nanofiber-Reinforced Hydrogels with Excellent Tissue Adhesion
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-09-03 , DOI: 10.1021/acsbiomaterials.1c00982 Hai Zhong 1 , Zhiyong Li 2 , Tianyu Zhao 1 , Yongming Chen 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-09-03 , DOI: 10.1021/acsbiomaterials.1c00982 Hai Zhong 1 , Zhiyong Li 2 , Tianyu Zhao 1 , Yongming Chen 1
Affiliation
|
Herein, we report a simple approach to modify hydrophobic PCL nanofibers by adsorption of a fiber-homologous amphiphilic triblock copolymer (PCL-b-PEG-b-PCL, PCEC). The modified PCL nanofibers were then utilized to reinforce a physical hydrogel, which was formed by micellar crosslinking of the same PCEC triblock copolymer. Therefore, the copolymer played a dual role in not only dispersing and stabilizing nanofibers but also additionally providing a framework for the hydrogel matrix. The mechanical strength of the hydrogel was significantly enhanced by addition of the modified PCL nanofibers, and the gel modulus can be tuned by varying the concentration of the copolymer and nanofibers. The effect of nanofiber size and content on the mechanical properties of the hydrogel matrices was studied. Different from hydrogel composites that were reinforced by 2D fiber meshes or 3D woven fiber networks, this free fiber-reinforced hydrogel can be readily injected to adapt to the environmental shape and self-heal. The hydrogel composites showed superior tissue adhesion properties compared to the commercially available fibrin glue, especially in muscle adhesion. Due to its injectable and self-healing properties, this nanofiber-reinforced hydrogel may have great potential as a new type of tissue sealant.
中文翻译：
通过物理吸附纤维同源两亲共聚物和纳米纤维增强水凝胶对纳米纤维进行表面改性，具有优异的组织粘附性
在此，我们报告了一种通过吸附纤维同源的两亲性三嵌段共聚物（PCL- b- PEG- b）来修饰疏水性 PCL 纳米纤维的简单方法。-PCL、PCEC）。然后利用改性的 PCL 纳米纤维来增强物理水凝胶，该水凝胶是通过相同 PCEC 三嵌段共聚物的胶束交联形成的。因此，该共聚物不仅在分散和稳定纳米纤维方面发挥双重作用，而且还为水凝胶基质提供了一个框架。通过添加改性的 PCL 纳米纤维，水凝胶的机械强度显着增强，凝胶模量可以通过改变共聚物和纳米纤维的浓度来调节。研究了纳米纤维尺寸和含量对水凝胶基质机械性能的影响。与由 2D 纤维网或 3D 编织纤维网络增强的水凝胶复合材料不同，这种游离的纤维增强水凝胶可以很容易地注入以适应环境形状和自我修复。与市售的纤维蛋白胶相比，水凝胶复合材料显示出优异的组织粘附特性，尤其是在肌肉粘附方面。由于其可注射性和自愈性，这种纳米纤维增强水凝胶可能具有作为新型组织密封剂的巨大潜力。
更新日期：2021-10-12
中文翻译：
通过物理吸附纤维同源两亲共聚物和纳米纤维增强水凝胶对纳米纤维进行表面改性，具有优异的组织粘附性
在此，我们报告了一种通过吸附纤维同源的两亲性三嵌段共聚物（PCL- b- PEG- b）来修饰疏水性 PCL 纳米纤维的简单方法。-PCL、PCEC）。然后利用改性的 PCL 纳米纤维来增强物理水凝胶，该水凝胶是通过相同 PCEC 三嵌段共聚物的胶束交联形成的。因此，该共聚物不仅在分散和稳定纳米纤维方面发挥双重作用，而且还为水凝胶基质提供了一个框架。通过添加改性的 PCL 纳米纤维，水凝胶的机械强度显着增强，凝胶模量可以通过改变共聚物和纳米纤维的浓度来调节。研究了纳米纤维尺寸和含量对水凝胶基质机械性能的影响。与由 2D 纤维网或 3D 编织纤维网络增强的水凝胶复合材料不同，这种游离的纤维增强水凝胶可以很容易地注入以适应环境形状和自我修复。与市售的纤维蛋白胶相比，水凝胶复合材料显示出优异的组织粘附特性，尤其是在肌肉粘附方面。由于其可注射性和自愈性，这种纳米纤维增强水凝胶可能具有作为新型组织密封剂的巨大潜力。
京公网安备 11010802027423号