Criss-crossing autism spectrum disorder and adult neurogenesis,Journal of Neurochemistry

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Criss-crossing autism spectrum disorder and adult neurogenesis
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2021-09-03 , DOI: 10.1111/jnc.15501
Frank Bicker ₁ , Leonardo Nardi ₁ , Jannik Maier ₁ , Verica Vasic ₁ , Michael J Schmeisser _{1,

2}

Affiliation

Autism spectrum disorder (ASD) comprises a group of multifactorial neurodevelopmental disorders primarily characterized by deficits in social interaction and repetitive behavior. Although the onset is typically in early childhood, ASD poses a lifelong challenge for both patients and caretakers. Adult neurogenesis (AN) is the process by which new functional neurons are created from neural stem cells existing in the post-natal brain. The entire event is based on a sequence of cellular processes, such as proliferation, specification of cell fate, maturation, and ultimately, synaptic integration into the existing neural circuits. Hence, AN is implicated in structural and functional brain plasticity throughout life. Accumulating evidence shows that impaired AN may underlie some of the abnormal behavioral phenotypes seen in ASD. In this review, we approach the interconnections between the molecular pathways related to AN and ASD. We also discuss existing therapeutic approaches targeting such pathways both in preclinical and clinical studies. A deeper understanding of how ASD and AN reciprocally affect one another could reveal important converging pathways leading to the emergence of psychiatric disorders.

中文翻译：

交叉自闭症谱系障碍和成人神经发生

自闭症谱系障碍 (ASD) 包括一组多因素神经发育障碍，主要特征是社交互动障碍和重复行为。尽管 ASD 通常在儿童早期发病，但 ASD 对患者和看护人来说都是终生的挑战。成人神经发生 (AN) 是从出生后大脑中存在的神经干细胞产生新的功能性神经元的过程。整个事件基于一系列细胞过程，例如增殖、细胞命运的规范、成熟以及最终突触整合到现有神经回路中。因此，AN 与终生的结构和功能大脑可塑性有关。越来越多的证据表明，受损的 AN 可能是 ASD 中一些异常行为表型的基础。在这次审查中，我们研究了与 AN 和 ASD 相关的分子通路之间的相互联系。我们还在临床前和临床研究中讨论了针对此类途径的现有治疗方法。更深入地了解 ASD 和 AN 如何相互影响可以揭示导致精神疾病出现的重要融合途径。

更新日期：2021-10-27

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