In this issue of JCB, Welch et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles. This explains how many resident proteins are retained at the Golgi and reveals a key role for GOLPH3 in maintaining Golgi homeostasis.

中文翻译：

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GOLPH3 让高尔基居民呆在家里


在本期 JCB 中，Welch 等人。 (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115)表明，GOLPH3 介导将大量高尔基体蛋白分类到回收 COPI 转运囊泡中。这解释了有多少常驻蛋白被保留在高尔基体中，并揭示了 GOLPH3 在维持高尔基体稳态中的关键作用。