Objective: Available conventional therapies are commonly used for the treatment of breast cancer, such as surgical procedures, hormonal therapy, radiation therapy, and chemotherapy. These therapies can be either given alone or in combination with other therapies. Various side effects associated with chemotherapies, including toxicity and multidrug resistance, have limited the use of chemotherapy, thus making it less effective than the above mentioned therapies. This review focus has been summarised as the application of anticancer with phytoconstituents that could be a promising and effective treatment strategy for breast cancer treatment.

Methods: This review is designed on relevant literature that was screened on the basis of in-scope criteria in the title, abstract, and keywords of the searched articles. The available literature was searched on PubMed, ScienceDirect, MedlinePlus, and Google scholar up to May 2021. A total of 47 articles were selected out of 168 articles based on inclusion and exclusion criteria.

Results: The major limitations accompanying available conventional treatment, mainly chemotherapy, include low bioavailability at the specific site of tumor cells, the occurrence of multidrug resistance, and high doserelated side effects. The phytoconstituents possessing anticancer properties and, when used in combination with chemotherapeutic agents, impart promising and potential therapeutic value. Many in vitro and in vivo studies showed that phytoconstituents could enhance the effectiveness of chemotherapy drugs for breast cancer treatment.

Conclusion: The combination approaches of phytoconstituents with chemotherapeutic drugs provide less toxicity to normal cells, reduce side effects, and overcome multidrug resistance, thus making the combination approaches an effective strategy for the treatment of breast cancer.

目的：现有的常规疗法通常用于治疗乳腺癌，如外科手术、激素疗法、放射疗法和化学疗法。这些疗法可以单独使用，也可以与其他疗法联合使用。与化学疗法相关的各种副作用，包括毒性和多药耐药性，限制了化学疗法的使用，因此使其不如上述疗法有效。这篇综述的重点总结为植物成分抗癌的应用，这可能是乳腺癌治疗的一种有前途和有效的治疗策略。

方法：本综述是根据检索到的文章的标题、摘要和关键词中的范围内标准筛选的相关文献设计的。截至 2021 年 5 月，在 PubMed、ScienceDirect、MedlinePlus 和 Google 学术上搜索了可用文献。根据纳入和排除标准，从 168 篇文章中选出了 47 篇文章。

结果：现有常规治疗（主要是化疗）的主要局限性包括肿瘤细胞特定部位的生物利用度低、多药耐药性的发生和高剂量相关的副作用。具有抗癌特性的植物成分，当与化学治疗剂结合使用时，具有有希望和潜在的治疗价值。许多体外和体内研究表明，植物成分可以提高化疗药物治疗乳腺癌的效果。

结论：植物成分与化疗药物的联合用药对正常细胞的毒性较小，副作用小，克服多药耐药，是治疗乳腺癌的有效策略。