Pneumonia is a common infectious disease with high morbidity and mortality. It is caused by a variety of pathogenic microorganisms that infect the lung parenchyma. Anti-infective drugs are one of the preferred choices for the treatment of pneumonia. Pachymic acid (PA) is a lanolin triterpene compound from Poria cocos, which has antiemetic, anti-inflamma-tory, and anticancer properties. Although PA inhibits inflammatory response in a variety of diseases, its role in pneumonia is not clear. In this study, we established that PA improved histopathological changes in the lungs of rats with pneumonia. PA inhibited the expression of inflammatory cytokines in the serum of rats having pneumonia. In addition, PA inhibited the apoptosis of cells from rat lung tissues. Mechanically, PA inhibited inflammation and cell apoptosis via NF-κB and MAPK pathways. Therefore, PA could serve as a promising drug for treating pneumonia.

中文翻译：

---

Pachymic acid 通过调节 NF-κB 和 MAPK 通路抑制脂多糖 (LPS) 诱导的肺炎大鼠模型中的炎症和细胞凋亡。

肺炎是一种常见的传染病，发病率和死亡率都很高。它是由感染肺实质的多种病原微生物引起的。抗感染药物是治疗肺炎的首选药物之一。茯苓酸 (PA) 是一种来自茯苓的羊毛脂三萜化合物，具有止吐、抗炎和抗癌的特性。虽然 PA 抑制多种疾病的炎症反应，但其在肺炎中的作用尚不清楚。在这项研究中，我们确定 PA 改善了肺炎大鼠肺部的组织病理学变化。PA抑制肺炎大鼠血清中炎性细胞因子的表达。此外，PA 抑制大鼠肺组织细胞的凋亡。机械地，PA 通过 NF-κB 和 MAPK 途径抑制炎症和细胞凋亡。