Hypertension, as one of the most common chronic diseases, is a major public health issue. Previous studies have shown that there are miRNAs differentially expressed in hypertensive patients. In addition, hypertension is closely related to endothelial dysfunction, and miRNAs have been identified as important molecular mediators for endothelial function. Therefore, it is necessary to identify specific miRNAs related to hypertension and explore their molecular mechanism in the progression of hypertension.

中文翻译：

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循环中的 miR-3656 通过靶向 eNOS 和 ADAMTS13（一种新型高血压生物标志物）诱导人脐静脉内皮细胞损伤。


高血压作为最常见的慢性病之一，是一个重大的公共卫生问题。此前的研究表明，高血压患者中存在差异表达的miRNA。此外，高血压与内皮功能障碍密切相关，miRNA已被确定为内皮功能的重要分子介质。因此，有必要鉴定与高血压相关的特异性miRNA并探讨其在高血压进展中的分子机制。