Maternal lifestyle and nutritional habits are associated with oocyte quality and ICSI clinical outcomes,Reproductive BioMedicine Online

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Maternal lifestyle and nutritional habits are associated with oocyte quality and ICSI clinical outcomes
Reproductive BioMedicine Online ( IF 3.7 ) Pub Date : 2021-09-03 , DOI: 10.1016/j.rbmo.2021.08.025
Amanda Souza Setti ₁ , Gabriela Halpern ₂ , Daniela Paes de Almeida Ferreira Braga ₁ , Assumpto Iaconelli ₁ , Edson Borges ₁

Affiliation

Research question

Do maternal lifestyle factors influence the incidence of oocyte dimorphisms and outcomes of intracytoplasmic sperm injection (ICSI) cycles?

Design

A total of 752 female patients undergoing an ICSI cycle at a private university-affiliated IVF centre from January 2015 to December 2019 were included in this historical cohort study. Before starting ovarian stimulation, participants completed a questionnaire on cigarette smoking habits, consumption of alcoholic beverages, refined sugar, artificial sweeteners, soft drinks, fruits, legumes and vegetables, milk and dairy, and meat, as well as exercise frequency over the past 6 months. Oocyte morphology was evaluated before ICSI. The influence of maternal lifestyle factors on the incidence of oocyte dimorphisms and ICSI outcomes was evaluated by multivariate general linear models and generalized linear models, adjusted for potential confounders. The main outcome measures were the incidence of oocyte dimorphisms per cycle and clinical outcomes.

Results

Lifestyle factors and nutritional habits such as cigarette smoking, and the consumption of alcohol, refined sugar and artificial sweeteners, were positively associated with incidence of several oocyte dimorphisms and negatively associated with the response to ovarian stimulation and embryo development. Negative relationships were also observed between these habits and clinical outcomes, apart from miscarriage rate, in which positive relationships were observed. Significant negative dose-dependent relationships between these habits and implantation rates were noted (P < 0.001). Alcoholic beverage consumption also showed inverse dose-dependent relationships with clinical pregnancy and live birth rates. Live birth rate was also negatively associated with cigarette smoking, in a dose-dependent manner.

Conclusions

Poor maternal habits were associated with reduced oocyte quality and ICSI outcomes in this study. Many of these associations were shown to be dose-dependent.

中文翻译：

母亲的生活方式和营养习惯与卵母细胞质量和 ICSI 临床结果有关

研究问题

母亲的生活方式因素是否会影响卵母细胞二态性的发生率和胞浆内单精子注射 (ICSI) 周期的结果？

设计

从 2015 年 1 月到 2019 年 12 月，共有 752 名在私立大学附属 IVF 中心接受 ICSI 周期的女性患者被纳入这项历史队列研究。在开始卵巢刺激之前，参与者完成了一份关于吸烟习惯、酒精饮料、精制糖、人造甜味剂、软饮料、水果、豆类和蔬菜、牛奶和奶制品、肉类以及过去 6 年的运动频率的问卷调查个月。在 ICSI 之前评估卵母细胞形态。通过多变量一般线性模型和广义线性模型评估母亲生活方式因素对卵母细胞二态性发生率和 ICSI 结果的影响，并针对潜在的混杂因素进行了调整。主要结果指标是每个周期卵母细胞二态性的发生率和临床结果。

结果

生活方式因素和营养习惯，如吸烟、饮酒、精制糖和人造甜味剂，与几种卵母细胞二态性的发生率呈正相关，与对卵巢刺激和胚胎发育的反应呈负相关。除了观察到正相关的流产率外，这些习惯和临床结果之间也观察到负相关。注意到这些习惯与植入率之间存在显着的负剂量依赖性关系（P < 0.001）。酒精饮料消费量也与临床妊娠率和活产率呈负剂量依赖性关系。活产率也与吸烟呈负相关，呈剂量依赖性。