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An Integrative Literature Review on the Nomenclature and Definition of Dementia at a Young Age
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-02 , DOI: 10.3233/jad-210458
Dennis van de Veen 1, 2, 3 , Christian Bakker 1, 2, 4 , Kirsten Peetoom 5 , Yolande Pijnenburg 6 , Janne M Papma 7 , , Marjolein de Vugt 7 , Raymond Koopmans 1, 2, 8
Affiliation  

Abstract

Background:

There has been growing interest in young people living with dementia. Future research requires consensus on the terminology and operational definition of this group.

Objective:

The purpose of this integrative review was to explore and include all operational definitions used to define dementia at a young age.

Methods:

On August 14, 2020, the PubMed, Embase, Cinahl, and PsycInfo databases were searched for empirical and theoretical literature using Google. Various terms to describe and define ‘dementia’ and ‘at a young age’ were used to collect literature concerning terminology; age-related aspects, including cut-off ages and criteria; and etiologies of dementia at a young age.

Results:

The search yielded 6,891 empirical and 4,660 theoretical publications, resulting in the inclusion of 89 publications, including 36 publications containing an explicit discussion and 53 publications as confirmation. ‘Young-onset dementia’ was the most commonly used term of seven identified terms, in the last two decades. The age of 65 years at symptom onset was used most frequently when considering a total of six upper age limits and four criteria to define a cut-off age. Eight lower age limits and an option for subdivision based on age were included. We identified 251 different etiologies and 27 categories of etiologies.

Conclusion:

Despite relative consensus on the term young-onset dementia and an age at symptom onset being used as a cut-off criterion, much is still unclear concerning possible etiologies of dementia at a young age. In the current study, controversies were detected for discussion in an international consensus study.



中文翻译:

年轻痴呆症的命名和定义综合文献综述

摘要

背景:

人们对患有痴呆症的年轻人越来越感兴趣。未来的研究需要就该组的术语和操作定义达成共识。

客观的:

本综合评价的目的是探索并包括所有用于定义年轻痴呆症的操作性定义。

方法:

2020 年 8 月 14 日,使用 Google 在 PubMed、Embase、Cinahl 和 PsycInfo 数据库中搜索了实证和理论文献。用于描述和定义“痴呆症”和“年轻时”的各种术语被用来收集有关术语的文献;与年龄相关的方面,包括截止年龄和标准;以及年轻时痴呆症的病因。

结果:

搜索产生了 6,891 篇实证出版物和 4,660 篇理论出版物,最终收录了 89 篇出版物,其中包括 36 篇包含明确讨论的出版物和 53 篇作为确认的出版物。在过去的 20 年里,“年轻发作的痴呆症”是七个确定的术语中最常用的术语。在考虑总共六个年龄上限和四个标准来定义截止年龄时,最常使用症状出现时的年龄 65 岁。包括八个较低的年龄限制和一个基于年龄的细分选项。我们确定了 251 种不同的病因和 27 种病因。

结论:

尽管对术语“年轻发作性痴呆”和症状出现的年龄被用作截止标准的相对共识,但关于年轻时痴呆的可能病因仍有很多不清楚。在当前的研究中,在一项国际共识研究中发现了争议以供讨论。

更新日期:2021-09-03
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