Cardiovascular disease (CVD) is associated with a higher risk of developing dementia. Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and tau burden, which are hallmark neuropathologies of Alzheimer’s disease (AD). Evidence for these associations during the preclinical stages of AD, when Aβ and tau pathologies first become detectable, is mixed. Quantifying the effect of vascular risk among cognitively normal individuals can help focus the efforts to develop therapeutic approaches aimed at modifying the course of preclinical AD.

中文翻译：

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在认知正常的老年人中，血管风险与阿尔茨海默病神经病理学的 PET 测量值无关

心血管疾病 (CVD) 与患痴呆症的风险较高有关。研究发现，血管危险因素与较大的淀粉样蛋白 β (Aβ) 和 tau 负荷有关，这是阿尔茨海默病 (AD) 的标志性神经病理学。在 AD 的临床前阶段，当 Aβ 和 tau 病理学首次变得可检测时，这些关联的证据是混合的。量化认知正常个体中血管风险的影响有助于集中精力开发旨在改变临床前 AD 病程的治疗方法。