Abstract

Colorectal cancers are one of the most common types of cancer. Gastric intestinal metaplasia is considered a precancerous lesion that can progress into gastric cancer. Even though there are previous reports that Helicobacter pylori and intestinal metaplasia are related to colorectal adenomas, there are also studies stating the opposite. This study aimed explored the relationship between gastric intestinal metaplasia and colorectal neoplasia. A total of 214 patients between the ages of 19 and 92 who underwent combined gastroscopy and colonoscopy between August 2016 and April 2020 were included in this retrospective study. Medical records including demographic data, gastroscopy and colonoscopy findings and histopathology results of the patients were reviewed and analyzed. The association of intestinal metaplasia and H. pylori infection with colorectal neoplasia was evaluated in these patients. The mean age of the patients included in the study was 49.07 ± 15.80, and 125 (58.4%) of the patients were male. A statistically significant correlation was found between intestinal metaplasia and colon neoplasm prevalence (p = 0.03). However, such a correlation was not seen between H. pylori and colon neoplasia. In conclusion, a positive correlation was found between gastric intestinal metaplasia, which is a precancerous lesion, and colon neoplasia. Even though this correlation indicates higher prevalence rates of colon neoplasia in patients with gastric intestinal metaplasia, how to evaluate these patients in terms of colon neoplasia remains a controversial issue.

摘要

结直肠癌是最常见的癌症类型之一。胃肠上皮化生被认为是一种癌前病变，可以发展为胃癌。尽管之前有报道称幽门螺杆菌和肠上皮化生与大肠腺瘤有关，也有研究表明相反。本研究旨在探讨胃肠化生与结直肠肿瘤的关系。该回顾性研究共纳入了 214 名年龄在 19 岁至 92 岁之间的患者，他们在 2016 年 8 月至 2020 年 4 月期间接受了胃镜和结肠镜联合检查。回顾和分析了包括人口统计学数据、胃镜检查和结肠镜检查结果以及患者的组织病理学结果在内的医疗记录。肠化生与幽门螺杆菌的关系在这些患者中评估了结直肠肿瘤的感染。纳入研究的患者的平均年龄为 49.07 ± 15.80，其中 125 (58.4%) 名患者为男性。肠上皮化生和结肠肿瘤患病率之间存在统计学上显着的相关性（p  = 0.03）。然而，在幽门螺杆菌和结肠瘤形成之间没有看到这种相关性。总之，发现作为癌前病变的胃肠化生与结肠瘤形成之间存在正相关。尽管这种相关性表明胃肠化生患者结肠肿瘤的患病率较高，但如何从结肠肿瘤方面评估这些患者仍然是一个有争议的问题。