Optimal physiological function throughout life is assured by activation, inhibition and/or modulation of multiple gene cascades resulting in new protein synthesis (possible biomarker), increased or decreased production of existing proteins, and other regulatory activities that maintain the organism in a relative healthy state for survival. Changes in physiological health state demand further (rapid) production/activation/inhibition/modulation of proteins that should ensure continued physiological functions in the short term, but these changes may not necessarily be ideal for long term survival. Medications, or even way of life changes, may help to stabilise overall organism's survival but cannot necessarily repair or reverse changes in gene expression already endured nor return the organism to an initial optimal healthy state.

通过激活、抑制和/或调节多个基因级联反应，导致新的蛋白质合成（可能的生物标志物）、增加或减少现有蛋白质的产生以及其他维持生物体处于相对健康状态的调节活动，确保整个生命的最佳生理功能为了生存。生理健康状态的变化需要进一步（快速）产生/激活/抑制/调节蛋白质，以确保短期内持续的生理功能，但这些变化不一定是长期生存的理想选择。药物，甚至生活方式的改变，可能有助于稳定整个生物体的生存，但不一定能修复或逆转已经忍受的基因表达的变化，也不能使生物体恢复到最初的最佳健康状态。