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Developed electrochemical sensors for the determination of beta-blockers: A comprehensive review
Journal of Electroanalytical Chemistry ( IF 4.1 ) Pub Date : 2021-09-03 , DOI: 10.1016/j.jelechem.2021.115666
Mohammad Reza Jalali Sarvestani 1 , Tayyebeh Madrakian 1, 2 , Abbas Afkhami 1, 3
Affiliation  

Beta-blockers (β-blockers) are a special type of medicine that are prescribed for a wide range of health problems including cardiovascular diseases. There is a narrow border between the therapeutic and toxic levels of β-blockers and at high dosages. β-blockers can cause serious side effects. Besides, β-blockers are used as a doping agent at some sports and their usages is banned by world anti-doping agency (WADA). Therefore, developing a simple, precise and sensitive methodology to determine β-blockers is greatly important. Among the different reported analytical approaches for β-blockers quantification, electroanalytical techniques offer high sensitivity, wide dynamic range, straightforward instrumentation, low price and short analysis time. The applicability in opaque and colored samples, high selectivity and the capability at determining several components simultaneously are other upsides of electrochemical sensors. In this regard, this review copes with critically comparing electrochemical sensors as well as measurement protocols for electroanalytical measurement of β-blockers. It is also highly concentrated on the employed working electrodes and their modification that are vital for effective determination. Moreover, important conclusions are made from the surveyed studies and some propositions are presented for future works.



中文翻译:

开发用于测定 β 受体阻滞剂的电化学传感器:全面审查

β-受体阻滞剂(β-受体阻滞剂)是一种特殊类型的药物,用于治疗包括心血管疾病在内的多种健康问题。β-受体阻滞剂的治疗水平和毒性水平以及高剂量之间的界限很窄。β-受体阻滞剂会引起严重的副作用。此外,β受体阻滞剂在某些运动中被用作兴奋剂,世界反兴奋剂机构(WADA)禁止使用。因此,开发一种简单、精确和灵敏的方法来确定 β 受体阻滞剂非常重要。在 β-受体阻滞剂定量的不同报告分析方法中,电分析技术提供高灵敏度、宽动态范围、简单的仪器、低价格和短分析时间。在不透明和有色样品中的适用性,高选择性和同时测定多个成分的能力是电化学传感器的其他优点。在这方面,本综述着重比较电化学传感器以及用于 β 受体阻滞剂电分析测量的测量方案。它还高度集中在对有效测定至关重要的所用工作电极及其修改上。此外,从调查的研究中得出了重要的结论,并对未来的工作提出了一些建议。它还高度集中在对有效测定至关重要的所用工作电极及其修改上。此外,从调查的研究中得出了重要的结论,并对未来的工作提出了一些建议。它还高度集中在对有效测定至关重要的所用工作电极及其修改上。此外,从调查的研究中得出了重要的结论,并对未来的工作提出了一些建议。

更新日期:2021-09-15
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