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A Synthesis of Spirooxindole-Isoindolinones Through Ugi Reaction Followed by Copper-Catalyzed Tandem C−N/C−C Coupling Process
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-09-02 , DOI: 10.1002/adsc.202100889 Xianqiang Zhong Zhong 1 , Jianghao Luo 1 , Wei Zhou 1 , Qian Cai 2
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-09-02 , DOI: 10.1002/adsc.202100889 Xianqiang Zhong Zhong 1 , Jianghao Luo 1 , Wei Zhou 1 , Qian Cai 2
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A synthesis of spiroindolinone-isoindolinone skeletons is presented. The protocol is through a Ugi four-component reaction followed by highly efficient and mild copper-catalyzed intramolecular tandem C−N/C−C coupling process. Control experiments demonstrated that the formation of C−C bond is a copper catalyzed coupling process rather than base promoted nucleophilic aromatic substitution pathway which proposed in Prof. Van der Eycken's palladium catalyst system previously.
中文翻译：
通过 Ugi 反应和铜催化串联 C−N/C−C 偶联工艺合成螺环吲哚-异吲哚啉酮
介绍了螺吲哚酮-异吲哚啉酮骨架的合成。该协议是通过 Ugi 四组分反应，然后是高效和温和的铜催化分子内串联 C-N/C-C 耦合过程。对照实验表明，CC 键的形成是铜催化的偶联过程，而不是之前 Van der Eycken 教授的钯催化剂体系中提出的碱促进的亲核芳香取代途径。
更新日期：2021-11-09
中文翻译：
通过 Ugi 反应和铜催化串联 C−N/C−C 偶联工艺合成螺环吲哚-异吲哚啉酮
介绍了螺吲哚酮-异吲哚啉酮骨架的合成。该协议是通过 Ugi 四组分反应，然后是高效和温和的铜催化分子内串联 C-N/C-C 耦合过程。对照实验表明，CC 键的形成是铜催化的偶联过程，而不是之前 Van der Eycken 教授的钯催化剂体系中提出的碱促进的亲核芳香取代途径。
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