Abstract

The aim of this study was a detailed examination of the synthesis of 3-methyleneisoindolinones comprising various functional groups. Methylmagnesuim bromide and PTSA was employed for the synthesis of these compounds. A wide range of 3-methyleneisoindolinones were afforded in good to excellent yields. On the other hand, 3-methyleneisoindolinones was also obtained by an efficient microwave method. The frame work of these derivatives was constructed from 2- acetylbenzoic acid and various primary amines via two-component reaction. The obtained compounds were characterized by ¹H NMR, ¹³C-NMR and IR and elemental analysis.

中文翻译：

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3-亚甲基异吲哚啉酮的两种合成路线合成与表征

摘要

本研究的目的是详细检查包含各种官能团的 3-亚甲基异吲哚酮的合成。甲基溴化镁和 PTSA 用于合成这些化合物。各种 3-亚甲基异吲哚啉酮以良好到极好的收率得到。另一方面，3-亚甲基异吲哚啉酮也可以通过有效的微波方法获得。这些衍生物的框架是由 2-乙酰苯甲酸和各种伯胺通过双组分反应构建的。所得化合物通过¹ H NMR、¹³ C-NMR 和 IR 以及元素分析进行​​表征。