Abstract

A chelating ligand of thioether with ONS donor Schiff base HL [(E)-2-(((2-(benzylthio)phenyl)imino)methyl)napthalen-1-ol] and its metal complexes (RuL₁ and RuL₂) have been synthesized. They have been characterized by UV–Vis, FTIR, ¹H NMR, ¹³C NMR, mass spectrometry methods. The formulas of the synthesized compounds have been confirmed by elemental analysis and magnetic susceptibility measurements. The binding ability studies of the ligand (HL) and its Ru complexes (RuL₁ and RuL₂), with calf-thymus DNA have been explored by the absorption titration method. The binding interaction study reveals that the ligand (HL) and the complex RuL₁ interact with CT-DNA through an intercalative mode of binding whereas the complex RuL₂ does not show any interaction with CT-DNA due to steric effect.

摘要

硫醚与ONS供体希夫碱HL[( E )-2-(((2-(苄基硫基)苯基)亚氨基)甲基)萘-1-醇]的螯合配体及其金属配合物(RuL ₁和RuL ₂ )具有被合成。它们已通过 UV-Vis、FTIR、¹ H NMR、¹³ C NMR、质谱方法进行表征。合成化合物的分子式已通过元素分析和磁化率测量确定。已经通过吸收滴定法探索了配体 (HL) 及其 Ru 复合物 (RuL ₁和 RuL ₂ ) 与小牛胸腺 DNA的结合能力研究。结合相互作用研究表明配体 (HL) 和复合体 RuL ₁通过插入式结合模式与 CT-DNA 相互作用，而复杂的 RuL ₂由于空间效应而未显示与 CT-DNA 的任何相互作用。