Introduction: Overweight and obesity are associated with a more severe COronaVirus Disease 19 (COVID-19). Adipose tissue-related chronic inflammation could be a promoter for the occurrence of the cytokine storm that predicts aggravation of COVID-19. The primary aim was to investigate if this increased risk for more severe COVID-19 was associated with a higher inflammatory response. Methods: We enrolled patients #x3c;75 years old hospitalized in a medical COVID-19 ward with SARS-CoV-2-related pneumonia. Patients were classified according to BMI as normal weight, overweight, and obesity. Laboratory parameters were measured at admission and every second day during the hospital stay. Results: Ninety patients (64.4% males; median age 61 years) were enrolled. Invasive mechanical ventilation (IMV) was needed in 9% of the patients with normal weight, in 32.4% of the patients with overweight, and in 12.9% of the patients with obesity (p = 0.045). Maximal C-reactive protein (CRP) level during hospital stay was 92 (48–122) mg/L in patients with normal weight, 140 (82–265) mg/L in patients with overweight, and 117 (67–160) mg/L in patients with obesity (p = 0.037). Maximal ferritin values were 564 (403–1,379) μg/L in patients with a normal weight, 1,253 (754–2,532) μg/L in patients with overweight, and 828 (279–1,582) μg/L in patients with obesity (p = 0.015). Conclusion: Patients with overweight and obesity required more IMV and had higher peaks of CRP and ferritin than patients with normal weight during COVID-19.
Obes Facts

中文翻译：

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超重和肥胖以及 SARS-CoV-2 相关肺炎患者的 C 反应蛋白和铁蛋白水平较高

简介：超重和肥胖与更严重的冠状病毒病 19 (COVID-19) 相关。脂肪组织相关的慢性炎症可能是预测 COVID-19 恶化的细胞因子风暴发生的促进因素。主要目的是调查这种更严重的 COVID-19 风险增加是否与更高的炎症反应有关。方法：我们招募了在 COVID-19 医疗病房住院的 SARS-CoV-2 相关肺炎患者 #x3c；75 岁。根据BMI将患者分为正常体重、超重和肥胖。在入院时和住院期间每隔一天测量实验室参数。结果：招募了 90 名患者（64.4% 男性；中位年龄 61 岁）。9% 的体重正常患者、32.4% 的超重患者和 12.9% 的肥胖患者需要有创机械通气 (IMV) ( p = 0.045)。住院期间，正常体重患者的最高 C 反应蛋白 (CRP) 水平为 92 (48-122) mg/L，超重患者为 140 (82-265) mg/L，117 (67-160) mg/L /L 肥胖患者 ( p = 0.037)。正常体重患者的最大铁蛋白值为 564 (403-1,379) μg/L，超重患者为 1,253 (754-2,532) μg/L，肥胖患者为 828 (279-1,582) μg/L（p = 0.015）。结论：在 COVID-19 期间，与体重正常的患者相比，超重和肥胖的患者需要更多的 IMV，并且 CRP 和铁蛋白的峰值更高。
肥胖事实