Objectives

The objective of this study was to investigate the effect of pimobendan on echocardiographic parameters of right ventricular and atrial function in healthy cats.

Animals

Eleven privately owned, healthy adult cats.

Material and methods

Each cat underwent five echocardiographic examinations: the first and second examinations were performed 1 h apart on day 0. On day 1, the third examination served as baseline, whereas the fourth and fifth examinations were performed one and 6 h after administration of a single oral dose of pimobendan (1.25 mg/cat), respectively. Parameters of right ventricular and atrial morphology and function were collected and compared among time points.

Results

Pimobendan administration produced a change in some echocardiographic variables. Specifically, heart rate, right ventricular fractional shortening and peak velocity of systolic lateral tricuspid annular motion increased (P = 0.032, P = 0.002 and P < 0.001, respectively), whereas right ventricular end-systolic internal diameter and right atrial maximum and minimum internal diameters decreased (P = 0.004, P = 0.025 and P = 0.01, respectively). Right ventricular fractional area change and tricuspid annular plane systolic excursion did not change.

Conclusions

This novel study showed that pimobendan had positive effects on right ventricular and right atrial function in healthy cats. Further studies are needed to determine whether pimobendan has similar effects in cats with cardiac diseases.

中文翻译：

---

单剂量匹莫苯对 11 只健康猫的右心室和右心房功能的影响

目标

本研究的目的是调查匹莫苯对健康猫右心室和心房功能的超声心动图参数的影响。

动物

11 只私人拥有的健康成年猫。

材料与方法

每只猫都接受了五次超声心动图检查：第一次和第二次检查在第 0 天相隔 1 小时进行。在第 1 天，第三次检查作为基线，而第四次和第五次检查在单次口服给药后 1 小时和 6 小时进行。匹莫苯 (1.25 mg/cat) 的剂量。收集右心室和心房形态和功能的参数并在时间点之间进行比较。

结果

Pimobendan 给药产生了一些超声心动图变量的变化。具体而言，心率、右心室缩短分数和收缩期外侧三尖瓣环运动的峰值速度增加（分别为P  = 0.032、P  = 0.002 和P  < 0.001），而右心室收缩末期内径和右心房最大和最小内径增加直径减小（分别为P  = 0.004、P  = 0.025 和P  = 0.01）。右心室面积分数变化和三尖瓣环平面收缩偏移没有变化。

结论

这项新颖的研究表明，匹莫苯对健康猫的右心室和右心房功能有积极影响。需要进一步的研究来确定匹莫苯对患有心脏病的猫是否有类似的影响。