Bioeconomy is seen as a way to mitigate the carbon footprint of human activities by reducing at least part of the fossil resources-based economy. In this new paradigm of sustainable development, the use of enzymes as biocatalysts will play an increasing role to provide services and goods. In industry, most of multicomponent enzyme cocktails are of fungal origin. Filamentous fungi secrete complex enzyme sets called “secretomes” that can be utilized as enzyme cocktails to valorize different types of bioresources. In this review, we highlight recent advances in the study of fungal secretomes using improved computational and experimental secretomics methods, the progress in the understanding of industrially important fungi, and the discovery of new enzymatic mechanisms and interplays to degrade renewable resources rich in polysaccharides (e.g. cellulose). We review current biotechnological applications focusing on the benefits and challenges of fungal secretomes for industrial applications with some examples of commercial cocktails of fungal origin containing carbohydrate-active enzymes (CAZymes) and we discuss future trends.

生物经济被视为通过减少至少部分以化石资源为基础的经济来减轻人类活动碳足迹的一种方式。在这种可持续发展的新范式中，酶作为生物催化剂的使用将在提供服务和商品方面发挥越来越大的作用。在工业中，大多数多组分酶混合物是真菌来源的。丝状真菌分泌称为“分泌酶”的复杂酶组，可用作酶混合物来评估不同类型的生物资源。在这篇综述中，我们重点介绍了使用改进的计算和实验分泌组学方法研究真菌分泌组的最新进展、对工业上重要真菌的理解进展，以及发现新的酶机制和相互作用以降解富含多糖的可再生资源（例如 纤维素）。我们回顾了当前的生物技术应用，重点关注真菌分泌组在工业应用中的优势和挑战，并列举了一些含有碳水化合物活性酶 (CAZymes) 的商业真菌混合物的例子，并讨论了未来的趋势。