Department of Chemical Engineering, Tsinghua University, Beijing, 100084, P. R. China.
The State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, P. R. China.
Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen, 518132, P. R. China.
National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, Tsinghua Shenzhen International Graduate School, Shenzhen, 518055, P. R. China.
College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, P. R. China.
Zn(OTf)2-catalyzed peroxidation of 1,3,5-triazines has been developed, accessing diversely substituted α-amino tertiary alkylperoxides with high efficiency under mild conditions. Moreover, the three-component reaction of amine, hydroperoxide, and paraformaldehyde was also proved to give the desired product. Mechanistic investigations and useful synthetic application of the products have also been presented.
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