Infection and inflammation are the main causes resulting in the failure of dental implants. In this work, molybdenum diselenide (MoSe₂) was synthesized hydrothermally on the surface of porous TiO₂ coating prepared by micro-arc oxidation on titanium (Ti) implants to render the coating excellent in situ antibacterial activity under the irradiation of near-infrared (NIR) light. Chitosan (CHI) was adsorbed on the surface of MoSe₂ nanosheets by electrostatic bonding to improve the biocompatibility. The introduction of MoSe₂ significantly improved the photothermal and photodynamic ability of TiO₂ coating and made the implants possess excellent in vitro and in vivo antibacterial property against Streptococcus mutans (S. mutans) under the irradiation of 808 nm NIR light for 15 min because of the synergistic of hyperthermia and reactive oxygen species (ROS). The immobilization of CHI improved the hydrophilicity and biocompatibility of MoSe₂, and the hybrid coating (TiO₂/MoSe₂/CHI) promoted osseointegration even in the presence of infection in vivo under 808 nm light irradiation. The light - assisted antibacterial coating described here has large clinical potential in dental implants applications.

感染和炎症是导致种植牙失败的主要原因。在这项工作中，在钛（Ti）植入物上通过微弧氧化制备的多孔TiO ₂涂层表面水热合成二硒化钼（MoSe ₂），使涂层在近红外辐射下具有优异的原位抗菌活性（近红外）光。壳聚糖（CHI）通过静电结合吸附在MoSe ₂纳米片的表面以提高生物相容性。MoSe ₂的引入显着提高了TiO ₂涂层的光热和光动力能力，使植入物具有优异的体外和由于高温和活性氧 (ROS) 的协同作用，在 808 nm 近红外光照射 15 分钟下对变形链球菌( S. mutans )具有体内抗菌性能。CHI 的固定化提高了 MoSe ₂的亲水性和生物相容性，即使在808 nm 光照射下，即使在体内存在感染的情况下，混合涂层（TiO ₂ /MoSe ₂ /CHI）也能促进骨整合。这里描述的光辅助抗菌涂层在牙科植入物应用中具有巨大的临床潜力。