当前位置: X-MOL 学术Org. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)–H and C(sp2)–H Bonds
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-03 , DOI: 10.1021/acs.orglett.1c02567
Zhuo Wu 1 , Zechen Wu 1 , Xueliang Sun 1 , Weixin Qi 1 , Zhengyang Zhang 1 , Yanghui Zhang 1
Affiliation  

Direct C–H/C–H coupling represents an appealing method for the construction of C–C bonds, and the cross-coupling of unactivated C(sp3)–H and C(sp2)–H bonds is challenging and remains to be investigated. We have developed the Pd-catalyzed intramolecular coupling of inert C(sp3)–H and C(sp2)–H bonds. The reaction proceeded by o-methyl oxime-directed aryl C(sp2)–H activation and subsequent alkyl C(sp3)–H cleavage, generating C(sp2),C(sp3)-palladacycles as the key intermediates. Dihydrobenzofurans and indanes were formed as the final products.

中文翻译:

钯催化未活化 C(sp3)–H 和 C(sp2)–H 键的分子内交叉偶联

直接 C-H/C-H 偶联是构建 C-C 键的一种有吸引力的方法,未活化的 C(sp 3 )-H 和 C(sp 2 )-H 键的交叉偶联具有挑战性,并且仍有待研究被调查。我们开发了 Pd 催化的惰性 C(sp 3 )-H 和 C(sp 2 )-H 键的分子内偶联。该反应通过甲基肟导向的芳基 C(sp 2 )-H 活化和随后的烷基 C(sp 3 )-H 裂解进行,生成 C(sp 2 ),C(sp 3 )-钯环作为关键中间体。最终产物形成二氢苯并呋喃和茚满。
更新日期:2021-09-17
down
wechat
bug