Gestational diabetes mellitus (GDM) is a special kind of diabetes that arises only during pregnancy. A woman with GDM has a higher risk of developing type-2 diabetes and other metabolic diseases. In this exploration, we intended to scrutinize the therapeutic actions of Myrtenol against the streptozotocin (STZ)-provoked GDM in rats. GDM was provoked in the pregnant rats via injecting the 1% of STZ (25 mg/kg) and then treated with the 50 mg/kg of myrtenol. The glucose level and bodyweight of animals were noted. The lipid profile, that is, total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein (HDL) was determined by respective kits. The lipid peroxidation and antioxidants status were examined using assay kits. The status of proinflammatory markers was investigated by assay kits. The messenger RNA (mRNA) expressions of TLR4/MyD88/NF-κB signaling proteins were studied by reverse transcription polymerase chain reaction analysis. The hepatic and pancreatic tissues were examined microscopically. Myrtenol treatment notably decreased the status of blood glucose and lipid profile and improved the HDL in the GDM rats. The status of lipid peroxidation and inflammatory markers were substantially reduced by the myrtenol and it enhanced the antioxidants status of GDM animals. Myrtenol treatment remarkably downregulated the mRNA expressions of TLR4/MyD88/NF-κB signaling proteins. The histological findings also proved the therapeutic actions of myrtenol. Altogether, the findings of this investigation unveiled the therapeutic actions of the myrtenol against the STZ-provoked GDM in rats. Myrtenol could be a promising therapeutic agent to treat GDM in the future.

中文翻译：

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Myrtenol 通过 TLR4/MyD88/NF-κB 信号通路减轻糖尿病妊娠大鼠的氧化应激和炎症

妊娠期糖尿病（GDM）是一种特殊的糖尿病，仅在怀孕期间出现。患有 GDM 的女性患 2 型糖尿病和其他代谢疾病的风险更高。在这次探索中，我们打算仔细检查 Myrtenol 对大鼠链脲佐菌素 (STZ) 诱发的 GDM 的治疗作用。通过注射 1% STZ (25 mg/kg) 在妊娠大鼠中诱发 GDM，然后用 50 mg/kg 桃金娘素治疗。记录动物的葡萄糖水平和体重。脂质谱，即总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白 (HDL) 由各自的试剂盒测定。使用检测试剂盒检查脂质过氧化和抗氧化剂状态。通过检测试剂盒研究促炎标志物的状态。通过逆转录聚合酶链反应分析研究了 TLR4/MyD88/NF-κB 信号蛋白的信使 RNA (mRNA) 表达。用显微镜检查肝和胰腺组织。Myrtenol 治疗显着降低了 GDM 大鼠的血糖和血脂状况并改善了 HDL。桃金娘素大大降低了脂质过氧化和炎症标志物的状态，并增强了 GDM 动物的抗氧化状态。Myrtenol 处理显着下调 TLR4/MyD88/NF-κB 信号蛋白的 mRNA 表达。组织学发现也证明了桃金娘素的治疗作用。总而言之，这项调查的结果揭示了桃金娘素对大鼠 STZ 诱发的 GDM 的治疗作用。