Abstract

Internationally, increasing numbers of children and adolescents with gender dysphoria are presenting for care. In response, gender-affirming therapeutic interventions that seek to align bodily characteristics with an individual’s gender identity are more commonly being used. Depending on a young person’s circumstances and goals, hormonal interventions may aim to achieve full pubertal suppression, modulation of endogenous pubertal sex hormone effects, and/or development of secondary sex characteristics congruent with their affirmed gender. This is a relatively novel therapeutic area and, although short-term outcomes are encouraging, longer term data from prospective longitudinal adolescent cohorts are still lacking, which may create clinical and ethical decision-making challenges. Here, we review current treatment options, reported outcomes, and clinical challenges in the pharmacological management of trans and gender-diverse adolescents.

中文翻译：

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患者治疗方法：跨性别和性别多元化青少年的药理学管理

 抽象的

在国际上，越来越多患有性别不安的儿童和青少年前来就诊。作为回应，寻求使身体特征与个人性别认同相一致的性别肯定治疗干预措施得到了更普遍的使用。根据年轻人的情况和目标，激素干预可能旨在实现全面的青春期抑制、内源性青春期性激素效应的调节和/或与其所确认的性别一致的第二性征的发育。这是一个相对新颖的治疗领域，尽管短期结果令人鼓舞，但仍缺乏前瞻性纵向青少年队列的长期数据，这可能会带来临床和伦理决策挑战。在这里，我们回顾了跨性别和性别多样化青少年药物管理中当前的治疗方案、报告的结果和临床挑战。