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Xylan-Based Cross-Linked Hydrogel for Photodynamic Antimicrobial Chemotherapy
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-09-02 , DOI: 10.1021/acsabm.1c00760
Abdechakour Elkihel 1 , Camille Christie 1 , Charlotte Vernisse 1 , Tan-Sothéa Ouk 1 , Romain Lucas 2 , Vincent Chaleix 1 , Vincent Sol 1
Affiliation  

Photodynamic antimicrobial chemotherapy or PACT has been shown to be a promising antibacterial treatment that could overcome the challenge of multidrug-resistant bacteria. However, the use of most existing photosensitizers has been severely hampered by their significant self-quenching effect, poor water solubility, lack of selectivity against bacterial cells, and possible damage to the surrounding tissues. The use of hydrogels may overcome some of these limitations. We herein report a simple strategy to synthesize a cross-linked hydrogel from beech xylan. The hydrogel showed a high swelling ratio, up to 62, an interconnected porous structure, and good mechanical integrity, and 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetraiodide (TMPyP) was chosen as a model of hydrophilic photosensitizer (PS) and was encapsulated inside the xylan-based hydrogel. TMPyP-loaded hydrogel prolonged release of PS up to 24 h with a cumulative amount that could reach 100%. TMPyP-loaded hydrogel showed a photocytotoxic effect against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus strains, and Bacillus cereus, while no cytotoxicity was observed in the dark.

中文翻译:

用于光动力抗菌化疗的基于木聚糖的交联水凝胶

光动力抗菌化学疗法或 PACT 已被证明是一种很有前途的抗菌治疗方法,可以克服多重耐药细菌的挑战。然而,大多数现有光敏剂的使用受到其显着的自猝灭效应、水溶性差、对细菌细胞缺乏选择性以及可能对周围组织造成损害的严重阻碍。水凝胶的使用可以克服其中一些限制。我们在此报告了一种从山毛榉木聚糖合成交联水凝胶的简单策略。水凝胶表现出高溶胀比,高达 62,相互连接的多孔结构和良好的机械完整性,以及 5、10、15、20-四(1-甲基吡啶鎓-4-基)卟啉四碘化物(TMPyP)被选为亲水性光敏剂(PS)的模型,并被封装在基于木聚糖的水凝胶内。负载 TMPyP 的水凝胶将 PS 的释放时间延长至 24 小时,累积量可达到 100%。负载 TMPyP 的水凝胶对铜绿假单胞菌大肠埃希菌金黄色葡萄球菌菌株和蜡状芽孢杆菌,而在黑暗中未观察到细胞毒性。
更新日期:2021-09-20
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