In this study, we aimed to achieve an efficient repair of damaged skeletal muscles using polyvinyl alcohol (PVA) soluble microneedle patches (MNP) loaded with carbonized wormwood and prostaglandin E2 (inflammatory factors). The introduction of carbonized wormwood imparted the MNP with near-infrared light heating characteristics that improved the efficiency of prostaglandin E2 delivery while also promoting circulation in the damaged muscle area. Our experimental results showed that, compared with the classical moxibustion treatment, the system could more quickly restore muscle strength and the cross-sectional area of muscle bundle fibers in a mouse model of muscular injury. In addition, it could also successfully induce the proliferation and differentiation of muscle stem cells to effectively repair injured muscle tissues. Above all, this light-controlled photothermal MN (microneedle) drug-delivery system avoided the common problems of traditional moxibustion such as large levels of smoke, slow efficacy and risk of scalding. Collectively, we put forward a safe, accurate and efficient approach for skeletal muscle damage treatment using carbonized wormwood.

中文翻译：

---

用于修复受损骨骼肌的碳化艾草改性光热微针贴片

在这项研究中，我们旨在使用载有碳化艾草和前列腺素 E2（炎症因子）的聚乙烯醇 (PVA) 可溶性微针贴片 (MNP) 实现对受损骨骼肌的有效修复。碳化艾草的引入赋予 MNP 近红外光加热特性，提高了前列腺素 E2 的输送效率，同时也促进了受损肌肉区域的循环。我们的实验结果表明，与经典艾灸治疗相比，该系统可以更快地恢复肌肉损伤小鼠模型的肌肉力量和肌束纤维的横截面积。此外，它还可以成功诱导肌肉干细胞的增殖和分化，从而有效修复受损的肌肉组织。首先，这种光控光热MN（微针）给药系统避免了传统灸法常见的烟雾量大、药效慢、烫伤风险等问题。我们共同提出了一种使用碳化艾草治疗骨骼肌损伤的安全、准确和有效的方法。