Abstract: At present, some bacteria have developed significant resistance to almost all available antibiotics. One of the reasons that cannot be ignored is long-term exposure of bacteria to the sub-minimum inhibitory concentration (MIC) of antibiotics. Therefore, it is necessary to develop a targeted antibiotic delivery system to improve drug delivery behavior, in order to delay the generation of bacterial drug resistance. In recent years, with the continuous development of nanotechnology, various types of nanocarriers that respond to the infection microenvironment, targeting specific bacterial targets, and targeting infected cells, and so on, are gradually being used in the delivery of antibacterial agents to increase the concentration of drugs at the site of infection and reduce the side effects of drugs in normal tissues. Here, this article describes in detail the latest research progress on nanocarriers for antimicrobial, and commonly used targeted antimicrobial strategies. The advantages of the combination of nanotechnology and targeting strategies in combating bacterial infections are highlighted in this review, and the upcoming opportunities and remaining challenges in this field are rationally prospected.

Keywords: nanocarriers, antimicrobial, drug delivery, targeting strategies


中文翻译：

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应用靶向给药系统和联合治疗的新兴抗菌策略

摘要：目前，一些细菌已经对几乎所有可用的抗生素产生了显着的耐药性。不可忽视的原因之一是细菌长期暴露于亚最低抑菌浓度（MIC）的抗生素。因此，有必要开发靶向抗生素递送系统来改善药物递送行为，以延缓细菌耐药性的产生。近年来，随着纳米技术的不断发展，各种响应感染微环境、靶向特定细菌靶点、靶向感染细胞等的纳米载体逐渐被用于抗菌剂的递送以提高浓度。减少感染部位的药物副作用，减少药物对正常组织的副作用。这里，本文详细介绍了纳米载体抗菌的最新研究进展，以及常用的靶向抗菌策略。这篇综述突出了纳米技术与靶向策略相结合在对抗细菌感染方面的优势，并对这一领域即将到来的机遇和面临的挑战进行了合理的展望。

关键词：纳米载体，抗菌，药物递送，靶向策略