Systemic lupus erythematosus (SLE) is a chronic inflammatory multi systematic disease of unknown aetiology. SLE has a wide range of symptoms. The most common symptoms are joint pain, skin rash and fever. Oral lesions in SLE manifest in a variety of forms, such as oral mucosal ulceration, mouth burns, xerostomia and salivary gland diseases, temporomandibular joint disease, periodontal disease, dysgeusia, white lesions, oedema, bleeding and petechiae. This study was conducted to evaluate the prevalence of oral mucosal lesions and their related factors in patients with SLE, giving the lack of comprehensive statistical data in Syria and the differences between reported prevalence. A cross-sectional study was performed in the Al-Mouassat University Hospital in Damascus. Patients were evaluated appropriating observation, clinical examination, completing questionnaires, studying patient’s medical records and paraclinical laboratory tests if required. Four types of oral lesions were evaluated: ulcer, erythema, white plaque and spots. The diagnosis of these lesions was made according to observation and clinical examination, and the location of each lesion was also recorded. Data were analysed using SPSS version 16.0. In this study, 42 (70% %) out of 60 patients (38 women and 4 men) had oral lesions, while 18 (30%) had none. The most common areas for the lesions were the buccal mucosa (26.1%) and the lips (14.2%). Of the 42 patients with oral lesions, 12 (27.6%) showed ulcers. There was a significant relationship between the following factors and oral lesions: oral hygiene status, the duration of the disease involvement, frequency of pregnancies, the amount of daily use of corticosteroids without significant difference between dosage groups, and medications used for SLE treatment other than corticosteroids (p < 0.008) without mentioned names or dosages. Conversely, age, sex, cigarette smoking and medications other than those used for SLE treatment were not significantly related to the presence of oral lesions (p value was greater than 0.05 in all subjects).

中文翻译：

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系统性红斑狼疮患者口腔黏膜病变发生情况及相关因素


系统性红斑狼疮（SLE）是一种病因不明的慢性炎症性多系统疾病。 SLE 有多种症状。最常见的症状是关节疼痛、皮疹和发烧。 SLE的口腔病变表现为多种形式，如口腔粘膜溃疡、口腔烧伤、口干和唾液腺疾病、颞下颌关节病、牙周病、味觉障碍、白斑、水肿、出血和瘀点等。鉴于叙利亚缺乏全面的统计数据以及报告的患病率之间的差异，本研究旨在评估 SLE 患者口腔粘膜病变的患病率及其相关因素。大马士革 Al-Mouassat 大学医院进行了一项横断面研究。对患者进行适当的观察、临床检查、填写问卷、研究患者的病历和临床旁实验室测试（如果需要）进行评估。评估了四种类型的口腔病变：溃疡、红斑、白斑和斑点。这些病变的诊断是根据观察和临床检查做出的，并记录每个病变的位置。使用 SPSS 16.0 版分析数据。在这项研究中，60 名患者（38 名女性和 4 名男性）中有 42 名（70% %）患有口腔病变，而 18 名患者（30%）没有口腔病变。最常见的病变部位是颊粘膜（26.1%）和嘴唇（14.2%）。 42例口腔病变患者中，12例（27.6%）出现溃疡。 以下因素与口腔病变之间存在显着关系：口腔卫生状况、疾病累及的持续时间、怀孕频率、每天使用皮质类固醇的量（剂量组之间无显着差异）以及用于治疗SLE以外的药物皮质类固醇（p < 0.008），未提及名称或剂量。相反，年龄、性别、吸烟和用于 SLE 治疗以外的药物与口腔病变的存在没有显着相关（所有受试者的 p 值均大于 0.05）。