Synthesis of [13C6]-ibrutinib,Journal of Labelled Compounds and Radiopharmaceuticals

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Synthesis of [13C6]-ibrutinib
Journal of Labelled Compounds and Radiopharmaceuticals ( IF 0.9 ) Pub Date : 2021-09-03 , DOI: 10.1002/jlcr.3944
Michal Kriegelstein ₁ , Miloš Hroch ₂ , Aleš Marek ₁

Affiliation

Convenient and straightforward synthesis of ibrutinib labeled by carbon-13 isotope is reported. Isotopically labeled building block is introduced in the last step of reaction sequence affording sufficient isolated yield (7%) of [¹³C₆]-ibrutinib calculated towards starting commercially available [¹³C₆]-bromobenzene.

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