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Synthesis of [13C6]-ibrutinib
Journal of Labelled Compounds and Radiopharmaceuticals ( IF 0.9 ) Pub Date : 2021-09-03 , DOI: 10.1002/jlcr.3944
Michal Kriegelstein 1 , Miloš Hroch 2 , Aleš Marek 1
Affiliation  

Convenient and straightforward synthesis of ibrutinib labeled by carbon-13 isotope is reported. Isotopically labeled building block is introduced in the last step of reaction sequence affording sufficient isolated yield (7%) of [13C6]-ibrutinib calculated towards starting commercially available [13C6]-bromobenzene.

中文翻译:

[13C6]-依鲁替尼的合成

报道了用碳 13 同位素标记的依鲁替尼的方便和直接的合成。在反应序列的最后一步中引入同位素标记的结构单元,提供足够的分离产率 (7%) [ 13 C 6 ]-依鲁替尼,计算起始于市售的 [ 13 C 6 ]-溴苯。
更新日期:2021-11-03
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