Objective: To evaluate the costs and cost-effectiveness of Shamiri-Digital, an online single-session intervention (SSI) for depression among Kenyan adolescents. Method: Data were drawn from a randomized clinical trial with n = 103 Kenyan high school students (64% female, Mage = 15.5). All students were eligible to participate, regardless of baseline depression symptomatology. We estimated delivery costs in 2020 U.S. dollars from multiple perspectives. To account for uncertainty, we performed sensitivity analyses with different cost assumptions and definitions of effectiveness. Using number needed to treat (NNT) estimates, we also evaluated the cost required to achieve a clinically meaningful reduction in depressive symptoms. Results: In the base-case (the most realistic cost estimate), it costs U.S. $3.57 per student to deliver Shamiri-Digital. Depending on the definition of clinically meaningful improvement, 7.1-9.7 students needed to receive the intervention for one student to experience a clinically meaningful improvement, which translated to a cost of U.S. $25.35 to U.S. $34.62 per student. Under a worst-case scenario (i.e., assuming the highest treatment cost and the strictest effectiveness definition), the cost to achieve clinically meaningful improvement was U.S. $92.05 per student. Conclusions: Shamiri-Digital is a low-cost intervention for reducing depression symptomatology. The public health benefit of empirically supported SSIs is especially important in low-income countries, where funding for mental health care is most limited. Future research can compare the cost-effectiveness of online SSIs to higher-cost treatments and estimate the robustness of Shamiri-Digital's effects over a longer time horizon. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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肯尼亚青少年抑郁症在线单次干预的经济评估。

目标：评估 Shamiri-Digital 的成本和成本效益，这是一种针对肯尼亚青少年抑郁症的在线单次干预 (SSI)。方法：数据来自一项随机临床试验，其中 n = 103 名肯尼亚高中生（64% 女性，法师 = 15.5）。无论基线抑郁症状如何，所有学生都有资格参加。我们从多个角度估算了 2020 美元的交付成本。为了考虑不确定性，我们使用不同的成本假设和有效性定义进行了敏感性分析。使用需要治疗的数量 (NNT) 估计值，我们还评估了实现抑郁症状有临床意义的减少所需的成本。结果：在基本情况下（最现实的成本估算），每名学生交付 Shamiri-Digital 的成本为 3.57 美元。根据临床意义改善的定义，7.1-9.7 名学生需要接受干预才能让一名学生体验临床意义改善，这意味着每位学生的成本为 25.35 美元至 34.62 美元。在最坏的情况下（即假设最高的治疗成本和最严格的有效性定义），实现有临床意义的改善的成本为每位学生 92.05 美元。结论：Shamiri-Digital 是一种减少抑郁症症状的低成本干预措施。经验支持的 SSI 的公共健康益处在低收入国家尤为重要，那里的精神卫生保健资金最为有限。未来的研究可以将在线 SSI 的成本效益与更高成本的治疗进行比较，并估计 Shamiri-Digital 的稳健性” s 的影响在更长的时间范围内。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。