Genetic predispositions play an important role in alcohol use. Understanding the psychosocial mechanisms through which genetic risk unfolds to influence alcohol use outcomes is critical for identifying modifiable targets and developing prevention and intervention efforts. In this study, we examined the role of sensation seeking and social support from family and friends in linking genetic risk to alcohol use. We also examined the role of social support in moderating the associations between genetic risk and sensation seeking and alcohol use. Data were drawn from a sample of 2,836 European American adults from the Collaborative Study on the Genetics of Alcoholism (46% male, mean age = 35.65, standard deviation [SD] = 10.78). Results from path analysis indicated that genome-wide polygenic scores for alcohol consumption (alc-GPS) were associated with higher sensation seeking, which in turn was associated with higher levels of alcohol use. alc-GPS was also associated with higher alcohol use indirectly via lower levels of family support. In addition, high friend support attenuated the association between alc-GPS and sensation seeking and alcohol use. The pattern of associations was similar for males and females, with some differences in the associations between social support and alcohol use observed across age. Our findings highlight the important role of intermediate phenotypes and gene-environment interplay in the pathways of risk from genetic predispositions to complex alcohol use outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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多基因风险、感觉寻求、社会支持和成年期饮酒之间的关联。

遗传倾向在饮酒中起着重要作用。了解遗传风险影响饮酒结果的社会心理机制对于确定可修改的目标以及制定预防和干预措施至关重要。在这项研究中，我们研究了感觉寻求和来自家人和朋友的社会支持在遗传风险与饮酒之间的联系中的作用。我们还研究了社会支持在调节遗传风险与感觉寻求和饮酒之间的关联方面的作用。数据取自酒精中毒遗传学合作研究的 2,836 名欧洲裔美国成年人样本（46% 为男性，平均年龄 = 35.65，标准差 [SD] = 10.78）。路径分析的结果表明，饮酒的全基因组多基因评分（alc-GPS）与更高的感觉寻求相关，而这反过来又与更高水平的饮酒相关。alc-GPS 还通过较低水平的家庭支持间接与较高的饮酒量相关。此外，高朋友支持度削弱了 alc-GPS 与感觉寻求和饮酒之间的关联。男性和女性的关联模式相似，但不同年龄阶段观察到的社会支持与饮酒之间的关联存在一些差异。我们的研究结果强调了中间表型和基因-环境相互作用在从遗传倾向到复杂的饮酒结果的风险途径中的重要作用。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。