Host–Guest Chemistry Triggered Differential HeLa Cell Behavior Based on Pillar[5]arene-Modified Graphene Oxide Surfaces,ACS Applied Bio Materials

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Host–Guest Chemistry Triggered Differential HeLa Cell Behavior Based on Pillar[5]arene-Modified Graphene Oxide Surfaces
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2021-09-01 , DOI: 10.1021/acsabm.1c00623
Xiaowei Mao ₁ , Ming Cheng ₂ , Linfeng Chen ₂ , Jing Cheng ₂ , Haibing Li ₂

Affiliation

The regulation of surface wettability and cell adhesion behavior in a mild and unperturbed state at the interface remains a challenging task. To address this task, we adopt a strategy, based on bridging the host–guest recognition capacities of pillar[5]arene and good attachment for cell adhesion abilities of graphene oxide, to construct a smart pillar[5]arene triazole-linked naphthalene-modified graphene oxide interface. The hybrid surface exhibited a good stimuli-responsive selectivity toward arginine, as demonstrated by the wettability and cell adhesion behavior. Further studies at molecular levels indicated that the recognition mechanism of arginine was probably due to the formation of a host–guest complex driven by π–π stacking interactions between the cavity of pillar[5]arenes and arginine, which eventually resulted in the change in surface wettability and cellular adhesion behavior. It not only signifies a host–guest interaction strategy for the design of smart devices via the host–guest effect but also inspires the design of high-performance biointerface for affinity-adherent cells without exposing cells to harsh physical and chemical conditions.

中文翻译：

基于 Pillar[5] 芳烃修饰的氧化石墨烯表面的主客体化学触发的差异 HeLa 细胞行为

在界面处以温和且不受干扰的状态调节表面润湿性和细胞粘附行为仍然是一项具有挑战性的任务。为了解决这一任务，我们采用了一种策略，基于桥接柱[5]芳烃的主客体识别能力和氧化石墨烯对细胞粘附能力的良好附着能力，构建了一种智能柱[5]芳烃三唑连接萘-改性氧化石墨烯界面。杂化表面对精氨酸表现出良好的刺激响应选择性，如润湿性和细胞粘附行为所证明的那样。分子水平的进一步研究表明，精氨酸的识别机制可能是由于柱[5]芳烃空腔与精氨酸之间的π-π堆积相互作用形成主客体复合物，最终导致表面润湿性和细胞粘附行为的变化。它不仅意味着通过主客效应设计智能设备的主客体交互策略，而且还启发了在不将细胞暴露于苛刻的物理和化学条件下的情况下为亲和贴壁细胞设计高性能生物界面。

更新日期：2021-09-20

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