Dynamics of circulating dendritic cells and cytokines after kidney transplantation—No effect of remote ischaemic conditioning,Clinical & Experimental Immunology

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Dynamics of circulating dendritic cells and cytokines after kidney transplantation—No effect of remote ischaemic conditioning
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2021-09-02 , DOI: 10.1111/cei.13658
Marie B Nielsen _{1,

2} , Kristian Ravlo _{1,

3} , Marco Eijken _{1,

4} , Nicoline V Krogstrup _{1,

5} , Morten Bue Svendsen ₁ , Chadi Abdel-Halim ₆ , Mikkel Steen Petersen ₄ , Henrik Birn _{1,

2} , Mihai Oltean ₇ , Bente Jespersen _{1,

3} , Bjarne K Møller ₄

Affiliation

Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of delayed graft function and possibly reduce long-term graft survival. Remote ischaemic conditioning may protect against ischaemia/reperfusion injury and mitigate the immunological response to the graft. We investigated the immunological effects of remote ischaemic conditioning on kidney transplantation from deceased donors in the randomized CONTEXT study. Three circulating dendritic cell (DC) subtypes identified in peripheral blood from kidney transplant recipients [myeloid DCs, plasmacytoid DCs and immunoglobulin-like transcript (ILT)3⁺ DCs] were measured at baseline, days 1, 3 and 5 and 1 and 3 months after transplantation. We also quantified 21 cytokines at baseline, days 1 and 5 and 3 months after transplantation. Neither DC counts nor cytokine levels differed between patients receiving remote ischaemic conditioning and controls; however, several parameters exhibited dynamic and parallel alterations in the two groups over time, reflecting the immunological response to the kidney transplantation and immunosuppression.

中文翻译：

肾移植后循环树突状细胞和细胞因子的动力学——远程缺血调理无影响

缺血/再灌注损伤引起的炎症可导致肾移植物功能障碍，增加移植物功能延迟的风险，并可能降低移植物的长期存活率。远程缺血调节可以防止缺血/再灌注损伤并减轻对移植物的免疫反应。我们在随机 CONTEXT 研究中调查了远程缺血预处理对已故供体肾移植的免疫学影响。在肾移植受者外周血中鉴定出三种循环树突状细胞 (DC) 亚型 [髓样 DC、浆细胞样 DC 和免疫球蛋白样转录物 (ILT)3 ⁺DCs] 在基线、移植后第 1、3 和 5 天以及 1 和 3 个月测量。我们还在基线、移植后第 1 天、第 5 天和第 3 个月量化了 21 种细胞因子。接受远程缺血调节和对照的患者之间的 DC 计数和细胞因子水平均无差异；然而，随着时间的推移，两组的几个参数表现出动态和平行的变化，反映了对肾移植和免疫抑制的免疫反应。

更新日期：2021-10-12

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