当前位置: X-MOL 学术Scand. J. Rheumatol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Complement C3d is not associated with axial spondyloarthritis and magnetic resonance imaging changes at the sacroiliac joint
Scandinavian Journal of Rheumatology ( IF 2.2 ) Pub Date : 2021-09-02 , DOI: 10.1080/03009742.2021.1946255
A Nygaard 1, 2 , O Hendricks 2, 3 , A G Loft 4, 5 , A A Christiansen 2, 3 , I Brandslund 2, 6 , A G Jurik 2, 4, 7 , B Schiøttz-Christensen 1, 2
Affiliation  

Objective

To investigate the associations between complement C3d and inflammatory and structural changes by magnetic resonance imaging (MRI) at the sacroiliac joints (SIJ) suggestive of axial spondyloarthritis, according to the Assessment of SpondyloArthritis international Society (ASAS) criteria, in patients with low back pain.

Method

This was a cross-sectional study of patients referred to the Spine Centre of Southern Denmark owing to unspecified low back pain (Spines of Southern Denmark cohort). The patients were divided into three groups: group 1: patients fulfilling the ASAS criteria for axial spondyloarthritis (axSpA, n = 96); group 2: patients with either a positive MRI of the SIJ and no spondyloarthritis features, or a negative MRI of the SIJ but positive human leucocyte antigen-B27 and one spondyloarthritis feature (non-axSpA, n = 38); group 3: patients with unspecified low back pain for > 3 months (control group, n = 82). Complement C3d was measured with double-decker rocket immunoelectrophoresis and evaluated in relation to the group division and baseline findings by SIJ MRI.

Results

In total, 184 C3d analyses were performed. The mean ± sd level of C3d was 33.8 ± 8.1 AU/mL. There were no differences in C3d levels between the three patient groups, mean values being: axSpA = 34.3 ± 7.9 AU/mL, non-axSpA = 33.5 ± 6.9 AU/mL, and controls = 33.4 ± 9.2 AU/mL. The level of C3d was not related to MRI findings.

Conclusions

In these patients, complement C3d was not associated with active or structural SIJ changes on MRI suggestive of axial spondyloarthritis.



中文翻译:

补体 C3d 与轴性脊柱关节炎和骶髂关节磁共振成像变化无关

客观的

根据国际脊柱关节炎协会 (ASAS) 的评估标准,在腰痛患者中通过骶髂关节 (SIJ) 磁共振成像 (MRI) 研究提示中轴型脊柱关节炎的补体 C3d 与炎症和结构变化之间的关联.

方法

这是一项针对因不明腰痛而转诊至南丹麦脊柱中心的患者(南丹麦脊柱队列)的横断面研究。将患者分为三组: 第 1 组:符合 ASAS 中轴型脊柱关节炎标准的患者(axSpA,n = 96);第 2 组:SIJ MRI 阳性且无脊柱关节炎特征的患者,或 SIJ MRI 阴性但人类白细胞抗原-B27 阳性且有一项脊柱关节炎特征的患者(非 axSpA,n = 38);第 3 组:未明确腰痛 > 3 个月的患者(对照组,n = 82)。用双层火箭免疫电泳测量补体 C3d,并根据 SIJ MRI 的组划分和基线结果进行评估。

结果

总共进行了 184 次 C3d 分析。C3d 的平均 ± sd 水平为 33.8 ± 8.1 AU/mL。三组患者的 C3d 水平没有差异,平均值为:axSpA = 34.3 ± 7.9 AU/mL,非 axSpA = 33.5 ± 6.9 AU/mL,对照组 = 33.4 ± 9.2 AU/mL。C3d 水平与 MRI 结果无关。

结论

在这些患者中,补体 C3d 与 MRI 提示中轴型脊柱关节炎的活动性或结构性 SIJ 变化无关。

更新日期:2021-09-02
down
wechat
bug