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Innovative methodology for marine collagen–chitosan–fucoidan hydrogels production, tailoring rheological properties towards biomedical application
Green Chemistry ( IF 9.3 ) Pub Date : 2021-08-20 , DOI: 10.1039/d1gc02223g
Duarte Nuno Carvalho 1, 2 , Cristiana Gonçalves 1, 2 , Joaquim Miguel Oliveira 1, 2 , David S. Williams 3 , Andrew Mearns-Spragg 3 , Rui L. Reis 1, 2 , Tiago H. Silva 1, 2
Affiliation  

Marine polymers such as collagen, chitosan, and fucoidan can be combined to form ionic-linked hydrogel networks towards applications in tissue engineering (TE). The use of greener approaches (as determined by green metrics – E-factor), including the absence of external chemical cross-linking agents, has advantages regarding the potential cytotoxicity. By tailoring the formulation of such an ionic-linked hydrogel, it is possible to fine-tune scaffold biofunctionality. In this study, a comparative study of composite hydrogels was accomplished, seeking to understand the correlation between polymer characteristics and physical behaviour to develop the applicability of this technology in soft-to-hard TE. Parameters such as polymer concentration, molecular weight, polymer-biomaterials bonds, biomaterial structural architecture, pore size, and mechanical rheological properties were directly correlated to the hydrogel's formulation. The results highlight that the formulation with greatest potential was the 3-component hydrogel (H12, followed by H10, H11), due to its superior mechanical properties, making it suitable for cartilage TE. This research offers a valuable perspective on hydrogel formulation and a new processing methodology, as well as how tailoring the hydrogel composition influences mechanical behaviour to support selecting the best composition for tissue engineering applications.

中文翻译:

海洋胶原蛋白-壳聚糖-岩藻多糖水凝胶生产的创新方法,为生物医学应用定制流变特性

海洋聚合物如胶原蛋白、壳聚糖和岩藻多糖可以结合形成离子连接的水凝胶网络,用于组织工程 (TE)。使用更环保的方法(由绿色指标决定 - E-因子),包括没有外部化学交联剂,在潜在的细胞毒性方面具有优势。通过定制这种离子连接水凝胶的配方,可以微调支架的生物功能性。在这项研究中,完成了复合水凝胶的比较研究,试图了解聚合物特性与物理行为之间的相关性,以开发该技术在软到硬 TE 中的适用性。聚合物浓度、分子量、聚合物-生物材料键、生物材料结构结构、孔径和机械流变特性等参数与水凝胶的配方直接相关。结果突出表明,具有最大潜力的配方是三组分水凝胶(H 12, 其次是 H 10 , H 11 ),由于其优越的机械性能,使其适用于软骨 TE。这项研究提供了关于水凝胶配方和新加工方法的宝贵观点,以及定制水凝胶组合物如何影响机械行为以支持为组织工程应用选择最佳组合物。
更新日期:2021-09-02
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