当前位置: X-MOL 学术Chem. Soc. Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Advanced biotechnology-assisted precise sonodynamic therapy
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-09-02 , DOI: 10.1039/d1cs00403d
Yi Zhang 1 , Xiangqian Zhang 2, 3 , Huocheng Yang 1 , Le Yu 4 , Yunjie Xu 4 , Amit Sharma 5 , Peng Yin 6 , Xiangyang Li 2 , Jong Seung Kim 4 , Yao Sun 1
Affiliation  

Despite significant advances, the therapeutic impact of photodynamic therapy is still substantially hampered by the restricted penetration depth of light and the reactive oxygen species (ROS)-mediated toxicity, which is impeded by the shorter effective half-life and radius of ROS produced during treatment. Sonodynamic therapy (SDT), on the other hand, provides unrivalled benefits in deep-seated tumour ablation due to its deep penetration depth and not totally ROS-dependent toxicity, exhibiting enormous preclinical and clinical potential. In this tutorial review, we highlight imaging-guided precise SDT, which allows choosing the best treatment option and monitoring the therapy response in real-time, as well as recent clinical trials based on SDT. Aside from that, the subtle design strategies of sonosensitizers based on tumour environment shaping and rational structure modification, as well as SDT combination treatment (chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy and immunotherapy), aimed at a more effective treatment outcome, are summarized. Finally, we discussed the future of SDT for personalized cancer and other disease treatments.

中文翻译:

先进的生物技术辅助精准声动力疗法

尽管取得了重大进展,但光动力疗法的治疗效果仍然受到光穿透深度的限制和活性氧 (ROS) 介导的毒性的严重阻碍,而治疗过程中产生的活性氧的有效半衰期和半径较短. 另一方面,声动力疗法 (SDT) 由于其深入的穿透深度和不完全依赖于 ROS 的毒性,在深部肿瘤消融中提供了无与伦比的优势,表现出巨大的临床前和临床潜力。在本教程回顾中,我们重点介绍了成像引导的精确 SDT,它允许选择最佳治疗方案并实时监测治疗反应,以及最近基于 SDT 的临床试验。除此之外,总结了基于肿瘤环境塑造和合理结构修饰的声敏剂的微妙设计策略,以及SDT联合治疗(化学疗法、化学动力学疗法、光动力疗法、光热疗法、气体疗法和免疫疗法),旨在获得更有效的治疗结果。 . 最后,我们讨论了 SDT 在个性化癌症和其他疾病治疗方面的未来。
更新日期:2021-09-02
down
wechat
bug