The development of multifunctional nanoformulations (NFs) include several features in a single nanosystem for these devices to overcome the disadvantages of inefficiency and undesirable toxicity of traditional therapies and provide new opportunities in the management of tumors. Herein, multifunctional CaO₂@Mn-PDA NFs with a core–shell structure, integrating the photothermal conversion properties of Mn-PDA, the chemodynamic properties of doped Mn ions, and relieving hypoxia in the tumor microenvironment (TME) were developed. The as-fabricated CaO₂@Mn-PDA NFs were embedded in microneedles (MNs) for transdermal delivery into tumor sites, leading to the generation of a new minimally invasive and synergistic therapeutic strategy against skin melanoma. Under near-infrared (NIR) light irradiation, the CaO₂@Mn-PDA NFs exhibited a synergistic therapeutic effect, including photothermal therapy (PTT), chemodynamic therapy (CDT), and modulating hypoxia due to their high photothermal conversion efficiency, boosted intracellular production of reactive oxygen species, excellent chemodynamic reactions, etc. Therefore, the developed MN platform, which can build implanted multifunctional characteristics for on-demand NIR-induced synergistic therapy, have a bright future in tumor suppression.

中文翻译：

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微针透皮递送多功能CaO2@Mn-PDA纳米制剂用于NIR诱导的皮肤黑色素瘤协同治疗

多功能纳米制剂 (NF) 的开发在单个纳米系统中为这些设备提供了多个功能，以克服传统疗法的低效和不良毒性的缺点，并为肿瘤管理提供新的机会。在此，开发了具有核-壳结构的多功能 CaO ₂ @Mn-PDA NF，结合了 Mn-PDA 的光热转换特性、掺杂 Mn 离子的化学动力学特性以及缓解肿瘤微环境 (TME) 中的缺氧。制备好的 CaO ₂@Mn-PDA NFs 嵌入微针 (MNs) 中，用于透皮递送到肿瘤部位，从而产生了一种针对皮肤黑色素瘤的新的微创和协同治疗策略。在近红外 (NIR) 光照射下，CaO ₂ @Mn-PDA NFs 表现出协同治疗作用，包括光热疗法 (PTT)、化学动力学疗法 (CDT) 和由于其高光热转换效率而调节缺氧，促进细胞内产生活性氧，优良的化学动力学反应等。因此，开发的MN平台可以为按需NIR诱导的协同治疗构建植入式多功能特征，在肿瘤抑制方面具有广阔的前景。