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Microneedle-mediated delivery of MIL-100(Fe) as a tumor microenvironment-responsive biodegradable nanoplatform for O2-evolving chemophototherapy
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-08-03 , DOI: 10.1039/d1bm00888a
Sulan Luo 1, 2 , Yiting Zhao 1 , Kewei Pan 1 , Yixian Zhou 1 , Guilan Quan 3 , Xinguo Wen 4 , Xin Pan 1 , Chuanbin Wu 3
Affiliation  

The low oxygen level in tumors significantly reduces the antitumor efficacy of photodynamic therapy (PDT). The provision of O2 and monomeric hydrophobic photosensitizers (PSs) under physiological conditions would greatly help to shrink malignant tumors. We take advantage of the high porosity and multifunctionality of metal–organic frameworks (MOFs) to fabricate a simple all-in-one nanoplatform mediated by microneedle delivery to achieve synergistic O2 evolution and chemophototherapy. An iron(III)-based MOF (MIL-100(Fe)) acted not only as a vehicle for the concurrent delivery of zinc phthalocyanine (ZnPc) and doxorubicin hydrochloride (Dox), but also to supply O2 by decomposing hydrogen peroxide (H2O2) in the tumor microenvironment via a Fenton-like reaction. In vitro and in vivo experiments indicated that the nanoplatform had excellent biocompatibility and exerted enhanced anticancer effects. The encapsulated drug was sustainably released from the nanoplatform skeleton in response to acidic tumor microenvironments. Moreover, upon 660 nm light irradiation, ZnPc effectively produced reactive oxygen species (ROS) due to the reduction of hypoxia by MIL-100(Fe). A microneedle technique was adopted to directly deliver the nanoplatform into superficial tumors rather than via systemic circulation. Hence, this study provides a new strategy for more efficient chemophototherapy of hypoxic superficial tumors.

中文翻译:

微针介导的 MIL-100(Fe) 作为肿瘤微环境响应的可生物降解纳米平台用于放氧化学光疗

肿瘤中的低氧水平显着降低了光动力疗法 (PDT) 的抗肿瘤功效。在生理条件下提供 O 2和单体疏水光敏剂 (PSs) 将极大地有助于缩小恶性肿瘤。我们利用金属有机框架 (MOF) 的高孔隙率和多功能性来制造一个简单的一体式纳米平台,通过微针输送来实现 O 2 进化和化学光疗的协同作用。基于铁 ( III ) 的 MOF (MIL-100(Fe)) 不仅可以作为同时输送锌酞菁 (ZnPc) 和盐酸多柔比星 (Dox) 的载体,还可以通过分解过氧化(氢气_ _2 ) 在肿瘤微环境中通过芬顿样反应。体外体内实验表明,该纳米平台具有良好的生物相容性,具有增强的抗癌作用。封装的药物响应酸性肿瘤微环境从纳米平台骨架中持续释放。此外,在 660 nm 光照射下,由于 MIL-100(Fe) 减少了缺氧,ZnPc 有效地产生了活性氧 (ROS)。采用微针技术将纳米平台直接输送到浅表肿瘤中,而不是通过体循环。因此,本研究为更有效的缺氧浅表肿瘤化学光疗提供了一种新策略。
更新日期:2021-09-02
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