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Mn(OAc)3 Induced C-4 Arylations of Quinazoline 3-Oxides with Arylboronic Acids
Synthesis ( IF 2.2 ) Pub Date : 2021-08-03 , DOI: 10.1055/a-1577-6344 Necdet Coşkun , Rashinikumar Samandram , Meliha Çetin Korukçu
Synthesis ( IF 2.2 ) Pub Date : 2021-08-03 , DOI: 10.1055/a-1577-6344 Necdet Coşkun , Rashinikumar Samandram , Meliha Çetin Korukçu
The use of manganese triacetate as an oxidant component in the C-4 arylations of 2-aryl-quinazoline 3-oxides with arylboronic acids is reported. The new protocol was applied to prepare new 2,4-diarylated quinazoline 3-oxides in good to high yields. The method was shown to tolerate various substituents on both aromatic rings, and no complications such as deoxygenation or rearrangement to quinazolin-4(3H)-one was observed.
中文翻译:
Mn(OAc)3 诱导喹唑啉 3-氧化物与芳基硼酸的 C-4 芳基化
据报道,在 2-芳基-喹唑啉 3-氧化物与芳基硼酸的 C-4 芳基化反应中,使用三乙酸锰作为氧化剂组分。新方案用于制备新的 2,4-二芳基化喹唑啉 3-氧化物,收率良好至高。该方法被证明可以耐受两个芳环上的各种取代基,并且没有观察到脱氧或重排为喹唑啉-4(3H)-one 等并发症。
更新日期:2021-09-02
中文翻译:
Mn(OAc)3 诱导喹唑啉 3-氧化物与芳基硼酸的 C-4 芳基化
据报道,在 2-芳基-喹唑啉 3-氧化物与芳基硼酸的 C-4 芳基化反应中,使用三乙酸锰作为氧化剂组分。新方案用于制备新的 2,4-二芳基化喹唑啉 3-氧化物,收率良好至高。该方法被证明可以耐受两个芳环上的各种取代基,并且没有观察到脱氧或重排为喹唑啉-4(3H)-one 等并发症。