The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43.3% (95% CI 34.6%–52.4%), negative percent agreement 100% (95% CI 99.4%–100%), positive predictive value 100% (95% CI 93.5%–100%), and negative predictive value 89.9% (95% CI 87.5%–92.0%). Among 127 rRT-PCR–positive specimens, the 55 with paired BinaxNOW-positive results had a lower mean cycle threshold than the 72 with paired BinaxNOW-negative results (17.8 vs. 28.5; p<0.001). Of 100 specimens with cycle threshold <30, a total of 51 resulted in positive virus isolation; 45 (88.2%) of those were BinaxNOW-positive. Our comparison supports immediate isolation for BinaxNOW-positive persons and confirmatory testing for negative persons.

在检测严重急性呼吸系统综合症冠状病毒 2 方面，雅培 BinaxNOW 快速抗原检测比实时逆转录 PCR (rRT-PCR) 更便宜、更快速。我们在冠状病毒疾病爆发期间对来自 342 人的 769 份配对样本进行了 BinaxNOW 与 rRT-PCR 的比较在美国加利福尼亚州的赛马场工人中。我们发现阳性百分比一致性为 43.3% (95% CI 34.6%–52.4%)，阴性百分比一致性为 100% (95% CI 99.4%–100%)，阳性预测值为 100% (95% CI 93.5%–100%)和阴性预测值 89.9% (95% CI 87.5%–92.0%)。在 127 个 rRT-PCR 阳性样本中，55 个具有配对 BinaxNOW 阳性结果的平均循环阈值低于具有配对 BinaxNOW 阴性结果的 72 个（17.8 对 28.5；p<0.001）。在循环阈值 <30 的 100 个样本中，共有 51 例病毒分离呈阳性；其中 45 人 (88.2%) 为 BinaxNOW 阳性。我们的比较支持对 BinaxNOW 阳性者的立即隔离和对阴性者的确认测试。