Lower bone resistance to load is due to the imbalance of bone homeostasis, where excessive bone resorption, compared with bone formation, determines a progressive osteopenia, leading to a high risk of fractures and consequent pain and functional limitations. Terpenoids, with their activities against bone resorption, have recently received increased attention from researchers. They are potentially more suitable for long-term use compared with traditional therapeutics. In this review of the literature of the past 5 years, we provide comprehensive information on terpenoids, with their anti-osteoporotic effects, highlighting molecular mechanisms that are often in epigenetic key and a possible pharmacological use in osteoporosis prevention and treatment.

较低的骨负荷阻力是由于骨稳态失衡，与骨形成相比，过度的骨吸收决定了进行性骨质减少，导致骨折的高风险以及随之而来的疼痛和功能限制。萜类化合物具有抗骨吸收的活性，最近受到了研究人员的越来越多的关注。与传统疗法相比，它们可能更适合长期使用。在这篇对过去 5 年文献的回顾中，我们提供了关于萜类化合物及其抗骨质疏松作用的全面信息，突出了通常在表观遗传关键中的分子机制以及在骨质疏松症预防和治疗中可能的药理学用途。