Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-supportive organ niche. Recent work investigating ECM changes that facilitate metastasis has revealed ways in which different metastatic organ niches are similar as well as the distinct characteristics that make them unique. In this review, we present recent findings regarding how ECM modifications support metastasis in four frequent metastatic sites: the lung, liver, bone, and brain. We discuss ways in which these modifications are shared between metastatic organs as well as features specific to each location. We also discuss areas of technical innovation that could be advantageous to future research and areas of inquiry that merit further investigation.

细胞外基质 (ECM) 的修饰是发展支持转移的器官生态位的一个关键方面。最近研究促进转移的 ECM 变化的工作揭示了不同转移器官生态位相似的方式以及使它们独特的独特特征。在这篇综述中，我们介绍了关于 ECM 修饰如何支持四个常见转移部位转移的最新发现：肺、肝、骨和脑。我们讨论了这些修改在转移器官之间共享的方式以及每个位置的特定特征。我们还讨论了可能有利于未来研究的技术创新领域和值得进一步研究的研究领域。