Despite the demonstrated efficacy and broad applicability of checkpoint blockade, the mechanisms by which it exerts its antitumor effects are incompletely understood. A recent article in Nature Medicine describes an ex vivo platform for assessing early responses to checkpoint blockade and the properties of tumor immune contexture in correlation to clinical responses.

中文翻译：

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肿瘤类器官来源的生物标志物可预测对 PD-1 阻断的免疫反应

尽管检查点阻断已被证明具有有效性和广泛的适用性，但其发挥抗肿瘤作用的机制尚不完全清楚。Nature Medicine最近的一篇文章描述了一个体外平台，用于评估对检查点封锁的早期反应以及与临床反应相关的肿瘤免疫环境的特性。