Biophysical modeling of development started with Alan Turing. His two-morphogen reaction-diffusion model was a radical but powerful simplification. Despite its apparent limitations, the model captured real developmental processes that only recently have been validated at the molecular level in many systems. The precision and robustness of reaction-diffusion patterning, despite boundary condition-dependence, remain active areas of investigation in developmental biology.

中文翻译：

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计算生物学：图灵的简单教训

开发的生物物理建模始于艾伦·图灵。他的双形态素反应扩散模型是一种激进但强大的简化。尽管存在明显的局限性，但该模型捕获了真正的发育过程，这些过程直到最近才在许多系统的分子水平上得到验证。尽管依赖于边界条件，反应扩散模式的精确性和稳健性仍然是发育生物学研究的活跃领域。