By coupling a quaternary pyridinium compound and curcumin (CM), a new antimicrobial agent called CP was obtained. The poor water-solubility was the most important limiting factor in the use of CM and CP. To address this problem, a hydrophilic hyperbranched polyglycerol (PG) was synthesized and reacted with CM and CP via Schiff base reaction to form two new macromolecules. Due to the presence of polymer, the solubility and stability of CM and CP increased significantly in aqueous media. Since the new macromolecules were including the hydrophilic polymeric and curcumin hydrophobic units, they self-assembled into spherical nanostructures, which were characterized by Field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) images. The synthetic nanostructures exhibited a controlled release of curcumin unit in the acidic environment. In vitro experiments showed that the new macromolecules are potent antibacterial and antioxidant agents.

通过将季吡啶化合物与姜黄素 (CM) 偶联，获得了一种称为 CP 的新型抗菌剂。水溶性差是CM和CP使用中最重要的限制因素。为了解决这个问题，合成了亲水性超支化聚甘油 (PG) 并通过席夫碱反应与 CM 和 CP 反应形成两个新的大分子。由于聚合物的存在，CM和CP在水性介质中的溶解度和稳定性显着增加。由于新的大分子包括亲水聚合物和姜黄素疏水单元，它们自组装成球形纳米结构，通过场发射扫描电子显微镜 (FE-SEM) 和透射电子显微镜 (TEM) 图像进行表征。合成纳米结构在酸性环境中表现出姜黄素单元的受控释放。体外实验表明，新的大分子是有效的抗菌剂和抗氧化剂。