After solid organ transplantation the cornerstone of immunosuppression is based on calcineurin inhibitors (CNIs), mostly tacrolimus. However, CNIs have a very narrow therapeutic window. The most important and serious side-effects of CNIs are nephrotoxicity, high blood pressure, post-transplant diabetes mellitus (PTMD), i.e., new-onset diabetes after transplantation (NODAT), dyslipidemia, and modification to the cardiovascular-risk profile. In this review, we will focus on tacrolimus-related toxicities in the setting of liver transplantation.

中文翻译：

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肝移植后免疫抑制的不良反应

实体器官移植后免疫抑制的基石是基于钙调神经磷酸酶抑制剂 (CNI)，主要是他克莫司。然而，CNI 的治疗窗很窄。CNIs 最重要和最严重的副作用是肾毒性、高血压、移植后糖尿病 (PTMD)，即移植后新发糖尿病 (NODAT)、血脂异常和心血管风险状况的改变。在这篇综述中，我们将重点关注肝移植中他克莫司相关的毒性。