当前位置：
X-MOL 学术
›
Appl. Organomet. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Synthesis and morphological studies of Tc-99m-labeled lupulone-conjugated Fe3O4@TiO2 nanocomposite, and in vitro cytotoxicity activity on prostate cancer cell lines
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2021-09-02 , DOI: 10.1002/aoc.6435 Elif Tutun 1 , Volkan Tekin 1 , Volkan Yasakcı 1 , Ömer Aras 2 , Perihan Ünak 1
Applied Organometallic Chemistry ( IF 3.7 ) Pub Date : 2021-09-02 , DOI: 10.1002/aoc.6435 Elif Tutun 1 , Volkan Tekin 1 , Volkan Yasakcı 1 , Ömer Aras 2 , Perihan Ünak 1
Affiliation
|
The purpose of this study was to develop a multifunctional theranostic probe for imaging (magnetic resonance imaging [MRI] and single-photon emission computed tomography [SPECT]) and therapy (photodynamic therapy). For this purpose, Tc-99m-labeled lupulone-conjugated Fe3O4@TiO2 nanocomposites (99mTc-DTPA-Fe3O4@TiO2-HLP and 99mTc-DTPA-Fe3O4@TiO2-ALP nanocomposites) were synthesized. The average diameter of the nanocomposites was 171 ± 20 nm as seen on transmission electron microscopy images. Fe3O4@TiO2 nanocomposites exhibited fluorescence spectra at an emission wavelength of 314 nm. Lupulone-conjugated Fe3O4@TiO2 nanocomposites were spherical-shaped with a suitable dispersion and without visible aggregation, and their radiolabeling yields were over 85%. Healthy (RWPE-1 normal human prostate epithelial cell line) and cancer prostate cell lines (PC-3 human prostate cancer cell line) were used to determine the in vitro biological behavior of the nanocomposites. The PC-3 cells treated with lupulone-conjugated Fe3O4@TiO2 nanocomposites showed a lower cell viability compared with RWPE-1 cells treated with lupulone-conjugated Fe3O4@TiO2 nanocomposites. Lupulone-modified Fe3O4@TiO2 nanocomposites may serve in the future as a multifunctional probe for positron emission tomography (PET)/MRI, photodynamic therapy, and hyperthermia therapy of cancer.
中文翻译：
Tc-99m 标记的蛇麻酮共轭 Fe3O4@TiO2 纳米复合材料的合成和形貌研究，以及对前列腺癌细胞系的体外细胞毒活性
本研究的目的是开发一种用于成像（磁共振成像 [MRI] 和单光子发射计算机断层扫描 [SPECT]）和治疗（光动力疗法）的多功能治疗诊断探针。为此，Tc-99m 标记的蛇麻酮共轭 Fe 3 O 4 @TiO 2纳米复合材料（99m Tc-DTPA-Fe 3 O 4 @TiO 2 -HLP 和99m Tc-DTPA-Fe 3 O 4 @TiO 2 -ALP纳米复合材料）被合成。如透射电子显微镜图像所示，纳米复合材料的平均直径为 171 ± 20 nm。Fe 3 O 4 @TiO2纳米复合材料在 314 nm 的发射波长下显示出荧光光谱。蛇麻酮共轭的Fe 3 O 4 @TiO 2纳米复合材料呈球形，分散度适中，无可见聚集，放射性标记率超过85%。健康（RWPE-1 正常人前列腺上皮细胞系）和癌症前列腺细胞系（PC-3 人前列腺癌细胞系）用于确定纳米复合材料的体外生物学行为。与用蛇麻酮缀合的 Fe 3 O 4处理的 RWPE-1 细胞相比，用蛇麻酮缀合的 Fe 3 O 4 @TiO 2纳米复合材料处理的 PC-3 细胞显示出较低的细胞活力@TiO 2纳米复合材料。蛇麻酮改性的 Fe 3 O 4 @TiO 2纳米复合材料在未来可能用作正电子发射断层扫描 (PET)/MRI、光动力疗法和癌症热疗的多功能探针。
更新日期：2021-09-02
中文翻译：
Tc-99m 标记的蛇麻酮共轭 Fe3O4@TiO2 纳米复合材料的合成和形貌研究，以及对前列腺癌细胞系的体外细胞毒活性
本研究的目的是开发一种用于成像（磁共振成像 [MRI] 和单光子发射计算机断层扫描 [SPECT]）和治疗（光动力疗法）的多功能治疗诊断探针。为此，Tc-99m 标记的蛇麻酮共轭 Fe 3 O 4 @TiO 2纳米复合材料（99m Tc-DTPA-Fe 3 O 4 @TiO 2 -HLP 和99m Tc-DTPA-Fe 3 O 4 @TiO 2 -ALP纳米复合材料）被合成。如透射电子显微镜图像所示，纳米复合材料的平均直径为 171 ± 20 nm。Fe 3 O 4 @TiO2纳米复合材料在 314 nm 的发射波长下显示出荧光光谱。蛇麻酮共轭的Fe 3 O 4 @TiO 2纳米复合材料呈球形，分散度适中，无可见聚集，放射性标记率超过85%。健康（RWPE-1 正常人前列腺上皮细胞系）和癌症前列腺细胞系（PC-3 人前列腺癌细胞系）用于确定纳米复合材料的体外生物学行为。与用蛇麻酮缀合的 Fe 3 O 4处理的 RWPE-1 细胞相比，用蛇麻酮缀合的 Fe 3 O 4 @TiO 2纳米复合材料处理的 PC-3 细胞显示出较低的细胞活力@TiO 2纳米复合材料。蛇麻酮改性的 Fe 3 O 4 @TiO 2纳米复合材料在未来可能用作正电子发射断层扫描 (PET)/MRI、光动力疗法和癌症热疗的多功能探针。
京公网安备 11010802027423号