Purpose:

Health utility, which is a measure of patient-reported outcome (PRO), has recently been used in health-related quality of life for patients with various cancers. However, the relationship between health utility and the physical function and of patients undergoing pleurectomy/decortication (P/D) as surgical treatment for malignant pleural mesothelioma (MPM) has not been reported in the perioperative and convalescent phases. This study aimed to evaluate the perioperative and postoperative health utility of patients undergoing P/D for MPM at one year postoperatively and to examine the relationship with physical function.

Methods:

We included patients underwent P/D. Grip strength, knee extension strength, 6-minute walk distance (6MWD), forced vital capacity (FVC), and forced expiratory volume in one second (FEV1) were measured to assess physical function, and the Short-Form Six-Dimension (SF-6D) was completed to assess health utility. These assessments were performed preoperatively, postoperatively, and one year postoperatively. Statistical analysis was performed using one-way analysis of variance for comparison of pre and postoperative and one year mean values.

Results:

There were 24 subjects (23 males, 65.5±8.3 year). SF-6D, 6MWD, FVC, and FEV1 values one year operatively improved significantly compared with postoperative. Additionally, SF-6D was correlated with 6MWD.

Conclusion:

Health utility were also correlated with exercise capacity.

中文翻译：

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恶性胸膜间皮瘤手术治疗患者身体机能与健康效用的关系

目的：

健康效用是衡量患者报告结果 (PRO) 的一个指标，最近已被用于各种癌症患者的健康相关生活质量。然而，在围手术期和恢复期尚未报道健康效用与身体机能之间的关系以及接受胸膜切除术/去皮质术 (P/D) 作为恶性胸膜间皮瘤 (MPM) 手术治疗的患者。本研究旨在评估接受 P/D 治疗 MPM 的患者在术后一年的围手术期和术后健康效用，并检查其与身体机能的关系。

方法：

我们纳入了接受 P/D 的患者。测量握力、膝伸力、6 分钟步行距离 (6MWD)、用力肺活量 (FVC) 和一秒用力呼气量 (FEV1) 以评估身体功能，以及短式六维 (SF -6D) 完成以评估健康效用。这些评估在术前、术后和术后一年进行。使用单向方差分析进行统计分析，以比较术前和术后以及一年的平均值。

结果：

共有 24 名受试者（23 名男性，65.5±8.3 岁）。SF-6D、6MWD、FVC 和 FEV1 值一年手术后较术后显着改善。此外，SF-6D 与 6MWD 相关。

结论：

健康效用也与运动能力相关。