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Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML
Molecular Cell ( IF 14.5 ) Pub Date : 2021-09-02 , DOI: 10.1016/j.molcel.2021.08.013 Samuel J Taylor 1 , Sriram Sundaravel 1 , Ulrich Steidl 1
中文翻译：
利用关键的转录依赖性：AML 中的 ZMYND8 和 IRF8
更新日期：2021-09-02
Molecular Cell ( IF 14.5 ) Pub Date : 2021-09-02 , DOI: 10.1016/j.molcel.2021.08.013 Samuel J Taylor 1 , Sriram Sundaravel 1 , Ulrich Steidl 1
Affiliation
In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.
中文翻译：
利用关键的转录依赖性：AML 中的 ZMYND8 和 IRF8
在本期《分子细胞》中，曹等人。(2021) 报告说 AML 细胞特别沉迷于 IRF8-MEF2D 基因表达网络。此外，他们将染色质阅读器 ZMYND8 确定为 IRF8-MEF2D 程序的上游调节剂，其活性对 AML 细胞存活至关重要。
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